Prevalence of asymptomatic deep vein thrombosis in patients hospitalized with SARS-CoV-2 pneumonia: a cross-sectional study
| Autor: | Samuele Lombi, Angelo Pan, Rossella Morandini, Anna Laura Nardecchia, Claudia Dellanoce, Vanessa Cancelli, Laura Romanini, Giancarlo Bosio, Matteo Giorgi-Pierfranceschi, Fabio De Gennaro, Oriana Paoletti, Maurizio Tala, Sophie Testa, Silvia Zambelli |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Cross-sectional study Deep vein Pneumonia Viral 030204 cardiovascular system & hematology Asymptomatic 03 medical and health sciences 0302 clinical medicine Internal medicine Prevalence Internal Medicine Humans Medicine 030212 general & internal medicine Point of care ultrasonography Vein Pandemics Aged Ultrasonography Aged 80 and over Venous Thrombosis business.industry Asymptomatic deep veins thrombosis COVID-19 Pneumonia Middle Aged medicine.disease Thrombosis Im - Original Pulmonary embolism Cross-Sectional Studies medicine.anatomical_structure Italy Asymptomatic Diseases Cohort Emergency Medicine Female medicine.symptom Coronavirus Infections Tomography X-Ray Computed business Covid-19 pneumonia |
| Zdroj: | Internal and Emergency Medicine |
| ISSN: | 1970-9366 1828-0447 |
| DOI: | 10.1007/s11739-020-02472-3 |
| Popis: | The association between coronavirus disease 2019 (COVID-19) pneumonia and venous thrombotic disorders is still unclear. We assessed the association between COVID-19 infection-related pneumonia and proximal deep-vein thrombosis (DVT) in a cohort of patients admitted to our hospital during the European outbreak in the front line of Cremona, Lombardy. In a single-center cross-sectional study, all patients hospitalized for more than 5 days in Internal Medicine Department with confirmed COVID-19 pneumonia received 2-point compressive ultrasound assessment (CUS) of the leg vein system during a single day. Ninety-four percent of patients received enoxaparin as standard pharmacological prophylaxis for venous thromboembolism. The presence of DVT was defined as incompressibility of popliteal or common femoral vein. Out of 121 patients with COVID-19 pneumonia (mean age 71.8, 66.3% males) hospitalized on March 31st, 70 stayed in hospital for over 5 days and 66 of them underwent CUS of deep venous system of the legs. The presence of asymptomatic DVT was found in 9 patients (13.6%). No symptomatic DVT was found. Patients with DVT showed mean age = 75.7 years, mean D-dimer levels = 4.02 ng/ml and all of them received enoxaparin for thromboprophylaxis, except one. Computed tomography pulmonary angiogram confirmed pulmonary embolism in five patients. One every seven patients with COVID-19-related pneumonia, hospitalized for more than 5 days, had asymptomatic proximal DVT and half of them had confirmed PE despite standard pharmacological thromboprophylaxis. This observational study suggests the need of an active surveillance through CUS in patients hospitalized with acute SARS-COV-2 and underline the need of a more intense thromboprophylaxis. |
| Databáze: | OpenAIRE |
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