Effects of propentofylline, a NGF synthesis stimulator, on alterations in muscarinic cholinergic receptors induced by basal forebrain lesion in rats
| Autor: | Saori Hayashi, Toshitaka Nabeshima, Tsutomu Kameyama, Masayuki Hiramatsu, Kazuyuki Fuji |
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| Rok vydání: | 1993 |
| Předmět: |
Male
medicine.medical_specialty Hippocampus Tritium Propentofylline Lesion chemistry.chemical_compound Prosencephalon Parietal Lobe Internal medicine Muscarinic acetylcholine receptor medicine Animals Nerve Growth Factors Rats Wistar Ibotenic Acid Basal forebrain General Neuroscience Receptors Muscarinic Frontal Lobe Rats Cortex (botany) Quinuclidinyl Benzilate Kinetics Endocrinology chemistry Xanthines Autoradiography Cholinergic medicine.symptom Ibotenic acid |
| Zdroj: | Neuroscience Letters. 150:99-102 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/0304-3940(93)90117-4 |
| Popis: | Basal forebrain (BF) lesions induced by ibotenic acid produced increases in the Bmax and Kd values of [3H]QNB binding sites in the frontal cortex, parietal cortex, and hippocampus. Twenty-eight-day successive administration of propentofylline (10 and 25 mg/kg, p.o.) significantly reduced the Kd values of [3H]QNB binding sites, to the levels of those in a sham group, in a dose-dependent manner. Moreover, propentofylline (25 mg/kg, p.o.) significantly reduced the Bmax value of [3H]QNB binding sites compared with that in a vehicle-treated BF-lesioned group. These results suggest that successive administration of propentofylline ameliorates changes in muscarinic cholinergic receptors through improving presynaptic cholinergic dysfunction. |
| Databáze: | OpenAIRE |
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