Sex differences in the association of prediabetes and type 2 diabetes with microvascular complications and function: The Maastricht Study
| Autor: | Annemarie Koster, Marleen M.J. van Greevenbroek, Carroll A.B. Webers, Simone J. P. M. Eussen, Tos T. J. M. Berendschot, Miranda T. Schram, Michiel L. Bots, Jos P. H. Reulen, Pieter C. Dagnelie, Rimke C. Vos, Marit de Jong, Rianneke de Ritter, Carla J.H. van der Kallen, Sanne A.E. Peters, Alfons J.H.M. Houben, Coen D.A. Stehouwer, Simone J. S. Sep |
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| Přispěvatelé: | Medical Image Analysis, MUMC+: HZC Klinische Neurofysiologie (5), Interne Geneeskunde, RS: Carim - V01 Vascular complications of diabetes and metabolic syndrome, MUMC+: *MA Oogheelkunde (3), Oogheelkunde, MUMC+: University Eye Center Maastricht (3), MUMC+: MA UECM Oogartsen MUMC (9), RS: MHeNs - R3 - Neuroscience, RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health, Epidemiologie, MUMC+: HVC Pieken Maastricht Studie (9), Sociale Geneeskunde, RS: CAPHRI - R4 - Health Inequities and Societal Participation, MUMC+: MA Interne Geneeskunde (3), MUMC+: Centrum voor Chronische Zieken (3), MUMC+: MA Med Staf Artsass Interne Geneeskunde (9), MUMC+: MA Endocrinologie (9), MUMC+: MA Maag Darm Lever (9), MUMC+: MA Hematologie (9), MUMC+: MA Medische Oncologie (9), MUMC+: MA Nefrologie (9), MUMC+: MA Reumatologie (9) |
| Rok vydání: | 2021 |
| Předmět: |
Blood Glucose
Male Epidemiology Endocrinology Diabetes and Metabolism Type 2 diabetes DETERMINANTS SDG 3 – Goede gezondheid en welzijn MELLITUS Diabetic Neuropathies Risk Factors Prevalence Diabetic Nephropathies Prediabetes Prospective Studies Netherlands Original Investigation education.field_of_study Middle Aged Prognosis Female Sex Cardiology and Cardiovascular Medicine Cohort study Adult medicine.medical_specialty Microvascular complications Population Risk Assessment Nephropathy DIET Prediabetic State Sex Factors SDG 3 - Good Health and Well-being Internal medicine Diabetes mellitus medicine Diseases of the circulatory (Cardiovascular) system Humans Women education Retinopathy Aged Diabetic Retinopathy business.industry Microcirculation Odds ratio Health Status Disparities medicine.disease Sex difference Neuropathy INDIVIDUALS Peripheral neuropathy Cross-Sectional Studies Diabetes Mellitus Type 2 RC666-701 RISK-FACTORS business PERIPHERAL NEUROPATHY Biomarkers Diabetic Angiopathies |
| Zdroj: | Cardiovascular Diabetology Cardiovascular Diabetology, 20:102. BioMed Central Cardiovascular Diabetology, 20(1):102. BioMed Central Ltd Cardiovascular Diabetology, Vol 20, Iss 1, Pp 1-15 (2021) Cardiovascular Diabetology, 20(1). BMC |
| ISSN: | 1475-2840 |
| Popis: | BackgroundWomen with type 2 diabetes are disproportionally affected by macrovascular complications; we here investigated whether this is also the case for microvascular complications and retinal microvascular measures.MethodsIn a population-based cohort study of individuals aged 40–75 years (n = 3410; 49% women, 29% type 2 diabetes (oversampled by design)), we estimated sex-specific associations, and differences therein, of (pre)diabetes (reference: normal glucose metabolism), and of continuous measures of glycemia with microvascular complications and retinal measures (nephropathy, sensory neuropathy, and retinal arteriolar and venular diameters and dilatation). Sex differences were analyzed using regression models with interaction terms (i.e. sex-by- (pre)diabetes and sex-by-glycemia) and were adjusted for potential confounders.ResultsMen with type 2 diabetes (but not those with prediabetes) compared to men with normal glucose metabolism, (and men with higher levels of glycemia), had significantly higher prevalences of nephropathy (odds ratio: 1.58 95% CI (1.01;2.46)) and sensory neuropathy (odds ratio: 2.46 (1.67;3.63)), larger retinal arteriolar diameters (difference: 4.29 µm (1.22;7.36)) and less retinal arteriolar dilatation (difference: − 0.74% (− 1.22; − 0.25)). In women, these associations were numerically in the same direction, but generally not statistically significant (odds ratios: 1.71 (0.90;3.25) and 1.22 (0.75;1.98); differences: 0.29 µm (− 3.50;4.07) and: − 0.52% (− 1.11;0.08), respectively). Interaction analyses revealed no consistent pattern of sex differences in the associations of either prediabetes or type 2 diabetes or glycemia with microvascular complications or retinal measures. The prevalence of advanced-stage complications was too low for evaluation.ConclusionsOur findings show that women with type 2 diabetes are not disproportionately affected by early microvascular complications. |
| Databáze: | OpenAIRE |
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