Superelasticity of plasma- and synthetic membranes resulting from coupling of membrane asymmetry, curvature, and lipid sorting
| Autor: | Tripta Bhatia, Piermarco Fonda, Rumiana Dimova, Fernanda S. C. Leomil, Reinhard Lipowsky, Ziliang Zhao, Jan Steinkühler |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Science
General Chemical Engineering General Physics and Astronomy Medicine (miscellaneous) plasma membrane Curvature Biochemistry Genetics and Molecular Biology (miscellaneous) Cell Line Tumor superelasticity Humans Surface Tension General Materials Science Elasticity (economics) Lipid bilayer Unilamellar Liposomes Research Articles lipid domains Chemistry Vesicle Cell Membrane General Engineering Phosphatidylglycerols Elasticity Sphingomyelins Coupling (electronics) Cholesterol Membrane Membrane curvature giant plasma membrane vesicles Biophysics spontaneous curvature micropipette synthetic biology Research Article Lumen (unit) |
| Zdroj: | Advanced Science bioRxiv Advanced Science, Vol 8, Iss 21, Pp n/a-n/a (2021) |
| Popis: | Biological cells are contained by a fluid lipid bilayer (plasma membrane, PM) that allows for large deformations, often exceeding 50% of the apparent initial PM area. Isolated lipids self‐organize into membranes, but are prone to rupture at small ( During their lifecycle, cells undergo remarkable deformations. The protective membrane holding together the cell (plasma membrane) must allow for such deformations. Here, plasma membrane extracts that retain some of the cellular deformability are studied. The underlying physics of the elastic response is identified and a synthetic biomaterial one magnitude softer and threefold more deformable than conventional synthetic cells is engineered. |
| Databáze: | OpenAIRE |
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