Expression of connective tissue growth factor in cartilaginous tumors
Autor: | Masaharu Takigawa, Hajime Inoue, Keiichiro Nishida, Nobuya Ohara, Takeshi Doi, Toshihiko Shakunaga, Toshifumi Ozaki, Akira Kawai, Koji Asaumi, Tohru Nakanishi |
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Rok vydání: | 2000 |
Předmět: |
Adult
Male Cancer Research Pathology medicine.medical_specialty Adolescent Chondrosarcoma Connective tissue Bone Neoplasms Immediate-Early Proteins Predictive Value of Tests Proliferating Cell Nuclear Antigen Enchondroma Humans Medicine Child Growth Substances integumentary system biology business.industry Cartilage Connective Tissue Growth Factor Cancer Middle Aged Prognosis medicine.disease Immunohistochemistry Survival Analysis Proliferating cell nuclear antigen CTGF medicine.anatomical_structure Oncology biology.protein Intercellular Signaling Peptides and Proteins Female Mitogens business Chondroma |
Zdroj: | Cancer. 89:1466-1473 |
ISSN: | 1097-0142 0008-543X |
Popis: | BACKGROUND Connective tissue growth factor (CTGF) predominantly is expressed in hypertrophic chondrocytes and its specific receptors are demonstrated on chondrocytic cells. Therefore, CTGF may be involved in the proliferation and/or differentiation of cartilage cells. In the current study, CTGF expression was examined both in chondrosarcoma and enchondroma to clarify the relation between the expression of CTGF and the grade of malignancy. METHODS The expression of CTGF and proliferating cell nuclear antigen (PCNA) were analyzed immunohistochemically in 34 cartilaginous tumor specimens. Eighteen tumors were determined to be chondrosarcoma including 8 Grade 1 tumors, 6 Grade 2 tumors, and 4 Grade 3 tumors. The percentage of CTGF positive and PCNA positive cells was quantified using at least 500 cells. RESULTS CTGF was expressed in 70.1% of enchondroma cells, 84.0% of Grade 1 chondrosarcoma cells, 53.7% of Grade 2 tumor cells, and 26.8% of Grade 3 tumor cells (ρ = −0.501; P = 0.0053). In chondrosarcoma cases, CTGF expression was correlated closely with tumor grade (ρ = −0.920; P = 0.0001). There was a strong correlation between PCNA expression and tumor grade (ρ = 0.907; P < 0.0001) and a strong negative correlation between CTGF and PCNA expression (ρ = −0.493; P = 0.0061). In chondrosarcoma cases, patients with high expression of CTGF (≥ 30%) showed higher overall survival compared with those with low expression (< 30%) (P = 0.004). CONCLUSIONS The current study revealed a correlation between the histologic grade of chondrosarcoma and prognosis, and the concomitant association between CTGF immunostaining and tumor grade and prognosis. Therefore, immunohistochemical staining with CTGF is a useful procedure for assessing the tumor grade and clinical course in patients with chondrosarcoma. Cancer 2000;89:1466–73. © 2000 American Cancer Society. |
Databáze: | OpenAIRE |
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