Novel mechanisms of the transendothelial migration of leukocytes
| Autor: | Mathew A. Vadas, Britta Engelhardt, Beat A. Imhof |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
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Transendothelial migration business.industry medicine.medical_treatment Leukocytes/ physiology Immunology Cell movement Gastric carcinoma Immunotherapy ddc:616.07 Endothelium Vascular/ cytology Cell Movement Inflammation Mediators/metabolism Animals Humans Immunology and Allergy Medicine Signal transduction business Signal Transduction |
| Zdroj: | Trends in Immunology, Vol. 22, No 8 (2001) pp. 411-414 |
| ISSN: | 1471-4906 |
| DOI: | 10.1016/s1471-4906(01)01961-5 |
| Popis: | and gastric carcinoma, do displayfeatures in their natural history andresponse to immunotherapy that areconsistent with recognition and targetingby lymphocyte-mediated effectormechanisms. It is a daunting propositionto pin down the failed immunemechanisms involved in the initiation ofcancer, given the rarity of patientshaving focal defects in the immunesystem (e.g.perforin deficiency) and thecoincident predisposition of suchindividuals to viral infection.Nevertheless, the recent description ofepithelial carcinomas in immuno-compromised mice |
| Databáze: | OpenAIRE |
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