Navigating the management of follicular variant papillary thyroid carcinoma subtypes: a classic PTC comparison
| Autor: | Toni Beninato, Rasa Zarnegar, David A. Kleiman, Thomas J. Fahey, Brendan M. Finnerty, Theresa Scognamiglio, Anna Aronova |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Lymphovascular invasion Lymph node metastasis Thyroid carcinoma Young Adult Surgical oncology Adenocarcinoma Follicular medicine Humans Thyroid Neoplasms Aged Neoplasm Staging Retrospective Studies Aged 80 and over business.industry Extranodal Extension Disease Management Middle Aged Prognosis Central lymph Management algorithm Adenocarcinoma Papillary Oncology Lymphatic Metastasis Thyroidectomy Surgery Female Follicular variant business Follow-Up Studies |
| Zdroj: | Annals of surgical oncology. 22(4) |
| ISSN: | 1534-4681 |
| Popis: | There are three subtypes of follicular variant papillary thyroid carcinoma (fvPTC): completely encapsulated, well circumscribed, and infiltrative. While infiltrative tumors are more aggressive than completely encapsulated, controversy exists regarding management of fvPTC subtypes. We compared the clinicopathologic features of fvPTC subtypes to those of classic PTC (cPTC) to help guide fvPTC management, using cPTC as a reference. A retrospective review was performed on 316 patients with PTC treated at a single institution from 2004 to 2011. There were 197 cPTC and 119 fvPTC tumors, including completely encapsulated (n = 46), well circumscribed (n = 46), and infiltrative (n = 27). Clinicopathologic data were compared between groups. fvPTC patients had larger tumors than cPTC patients (1.6 cm vs. 1.2 cm, p = 0.001), but age, sex, and family history did not differ. Thirty-one percent of cPTC tumors had extrathyroidal extension compared to 0 % of completely encapsulated, 0 % of well-circumscribed, and 52 % of infiltrative fvPTC tumors (p |
| Databáze: | OpenAIRE |
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