Insulin Resistance Is Not Increased in Inflammatory Bowel Disease Patients but Is Related to Non-Alcoholic Fatty Liver Disease
| Autor: | Noemi Hernández Alvarez-Buylla, Alejandro Hernández-Camba, Laura Ramos, Inmaculada Alonso-Abreu, Anjara Hernández-Pérez, Marta Carrillo-Palau, Miguel A. González-Gay, Laura Arranz, Manuel Hernández-Guerra, M Vela, Iván Ferraz-Amaro |
|---|---|
| Přispěvatelé: | Universidad de Cantabria |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
nonalcoholic fatty liver disease
medicine.medical_specialty medicine.medical_treatment Population Disease Gastroenterology Inflammatory bowel disease Article 03 medical and health sciences 0302 clinical medicine Insulin resistance inflammatory bowel disease Internal medicine insulin resistance Nonalcoholic fatty liver disease medicine education 030203 arthritis & rheumatology education.field_of_study business.industry Insulin Fatty liver General Medicine medicine.disease digestive system diseases Medicine 030211 gastroenterology & hepatology business Transient elastography |
| Zdroj: | Journal of Clinical Medicine Journal of Clinical Medicine, Vol 10, Iss 3062, p 3062 (2021) J Clin Med . 2021 Jul 10;10(14):3062 UCrea Repositorio Abierto de la Universidad de Cantabria Universidad de Cantabria (UC) Volume 10 Issue 14 |
| ISSN: | 2077-0383 |
| Popis: | Background. Insulin resistance (IR) has been linked to inflammatory states. The aim of this study was to determine whether IR is increased in a cohort of inflammatory bowel disease (IBD) patients with low disease activity. We additionally intended to establish which factors were the determinants of IR in this population, including the presence of nonalcoholic fatty liver disease (NAFLD). Methods. Cross-sectional study encompassing 151 IBD patients and 174 non-diabetic controls. Insulin and C-peptide serum levels and IR and beta cell function (%B) indices based on homoeostatic model assessment (HOMA2) were assessed in patients and controls. Liver stiffness as measured by transient elastography, and the presence of NAFLD detected via ultrasound were additionally assessed. A multivariable regression analysis was performed to evaluate the differences in IR indexes between patients and controls, and to determine which predictor factors were associated with IR in IBD patients. Results. Neither HOMA2-IR (beta coef. −0.26 {95%CI −0.64–0.13}, p = 0.19) nor HOMA2-%B (beta coef. 15 {95%CI −14–44}, p = 0.31) indexes differed between patients and controls after fully multivariable analysis. Among classic IR risk factors, obesity, abdominal circumference, and triglycerides significantly and positively correlated with IR indexes in IBD patients. However, most features related to IBD, such as disease patterns, disease activity, and inflammatory markers, were not associated with IR. The presence of NAFLD was independently and significantly associated with beta cell dysfunction in patients with IBD (HOMA2—B grade 4, 251 ± 40 vs. grade 1, 107 ± 37, p = < 0.001). Conclusions. IR is not increased in IBD patients with low disease activity compared to controls. However, the presence of NAFLD favors the development of IR in patients with IBD. |
| Databáze: | OpenAIRE |
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