Magnetic Resonance Imaging of Cerebral Lesions in Patients with the Sjögren Syndrome
| Autor: | Elaine L. Alexander, Thomas T. Provost, George D. Yannakakis, Nicholas Patronas, Henry F. McFARLAND, Ola A. Selnes, Steven S. Beall, Barry Gordon |
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| Rok vydání: | 1988 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Central nervous system Periventricular white matter Sjögren syndrome Central nervous system disease Axial tomography Central Nervous System Diseases Internal Medicine medicine Humans In patient Aged Aged 80 and over medicine.diagnostic_test business.industry Mental Disorders Brain Magnetic resonance imaging General Medicine Middle Aged medicine.disease Magnetic Resonance Imaging Cerebral Angiography Sjogren's Syndrome medicine.anatomical_structure Female Radiology Cognition Disorders Tomography X-Ray Computed business Cerebral angiography |
| Zdroj: | Annals of Internal Medicine. 108:815 |
| ISSN: | 0003-4819 |
| DOI: | 10.7326/0003-4819-108-6-815 |
| Popis: | Thirty-eight patients with the primary Sjögren syndrome, 16 with active neuropsychiatric manifestations and 22 without clinical evidence of central nervous system involvement had magnetic resonance (MR) imaging. Eight patients had focal neurologic deficits (6 of these also had psychiatric, or cognitive dysfunction), and 8 had psychiatric or cognitive abnormalities alone. Magnetic resonance imaging showed abnormal results in 12 of 16 (75%; 95% CI, 48 to 93) patients with active central nervous system disease (67 focal lesions predominantly within the subcortical and periventricular white matter), and in 2 of 22 (9%; 95% CI, 1 to 29) patients without clinical evidence of central nervous system disease (P less than 0.0001). Seven of eight patients with focal neurologic deficits and 5 of 8 patients with psychiatric or cognitive dysfunction alone had abnormal results on MR imaging. Magnetic resonance imaging was more sensitive in the subgroup with focal deficits, (sensitivity, 88%; 95% CI, 44 to 97) than computerized axial tomography or cerebral angiography. Magnetic resonance imaging detects focal cerebral lesions in patients with the Sjögren syndrome and central nervous system involvement, including patients with psychiatric and cognitive dysfunction alone. |
| Databáze: | OpenAIRE |
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