Non-pharmacological treatments for COVID-19: current status and consensus

Autor: Gabriella Lelis Silva, Mariana Ribeiro Brandão, Cassiana Gabriela Lima Barreto, Adriano O. Andrade, Angélica de Andrade Palis, José Flávio Viana Guimarães, Verônica de Lima Gonçalves, Fernanda de Paula Silva, Ariana Moura Cabral, Daniel Baldoino de Souza, Laureane Almeida Santiago de Araújo, Selma Terezinha Milagre, Fernando Pasquini Santos, Luanne Cardoso Mendes, Victor Hugo de Freitas Morales, Adriano Alves Pereira, Viviane da Conceição Lima, Lígia Reis Nóbrega
Rok vydání: 2021
Předmět:
Zdroj: Research on Biomedical Engineering
ISSN: 2446-4740
2446-4732
DOI: 10.1007/s42600-020-00116-1
Popis: Purpose COVID-19 is a disease caused by SARS-CoV-2 (coronavirus type 2 of the severe acute respiratory syndrome), isolated in China, in December 2019. The strategy currently used by physicians is to control disease and to treat symptoms, including non-pharmacological treatments, as there is still no specific treatment for COVID-19. Thus, the aim of this article is to carry out a systematic review about non-pharmacological treatments used for COVID-19, addressing current status and consensus found in the literature. Methods Three databases were consulted for evidence referring to the drugs indicated for COVID-19 (Cochrane Central, MEDLINE and Embase). The following terms and combinations were used: ((“2019-nCoV” OR 2019nCoV OR nCoV2019 OR “nCoV-2019” OR “COVID-19” OR COVID19 OR “HCoV-19” OR HCoV19 OR CoV OR “2019 novel*” OR Ncov OR “n-cov” OR “SARS-CoV-2” OR “SARSCoV-2” OR “SARSCoV2” OR “SARSCoV2” OR SARSCov19 OR “SARS-Cov19” OR “SARS-Cov-19”) OR “severe acute respiratory syndrome*” OR ((corona* OR corono*) AND (virus* OR viral* OR virinae*)) AND ((“lung injury”) OR (“ventilation use”) OR (“respiratory injuries” OR prone)) AND (treatment)) NOT Drugs NOT medicines NOT antivirals. Results A total of 28 articles were selected. These articles adopted one or more treatment methods for patients with severe cases of COVID-19, i.e., oxygen therapy, prone position, inhaled nitric oxide, intravenous infusion, passive immunotherapy, mesenchymal stem cells (MSC). Conclusion There is still no specific treatment approved for patients with COVID-19. The available evidence is not able yet to indicate the benefits or harms of non-pharmacological treatments, but some studies show that some treatments can play an important role in relation to COVID-19. The current consensus among researchers is that several studies using a randomized clinical trial should be carried out to provide evidence of safety and efficacy of the proposed treatments.
Databáze: OpenAIRE
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