Investigation of the degradation of arsenobetaine during its contact with natural zeolites and the identification of metabolites using HPLC coupled with ICP-MS and ESI-MS
| Autor: | Daniela Möller, Maria de la Paz Elizalde Gonzalez, Rainer Wennrich, Jiirgen Mattusch |
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| Rok vydání: | 2008 |
| Předmět: |
Spectrometry
Mass Electrospray Ionization Electrospray Chemical ionization Time Factors Chromatography Electrospray ionization Reproducibility of Results chemistry.chemical_element Mass spectrometry Nitric Acid Sensitivity and Specificity Biochemistry Arsenicals Mass Spectrometry Analytical Chemistry chemistry.chemical_compound Column chromatography chemistry Zeolites Arsenobetaine Inductively coupled plasma mass spectrometry Chromatography High Pressure Liquid Arsenic |
| Zdroj: | Analytical and Bioanalytical Chemistry. 390:1707-1715 |
| ISSN: | 1618-2650 1618-2642 |
| DOI: | 10.1007/s00216-008-1881-7 |
| Popis: | Combined detection by inductively coupled mass spectrometry (ICP-MS) for elemental information (quantification) and electrospray ionization mass spectrometry (ESI-MS) for molecular information (identification) by means of splitting of the eluent after chromatographic separation is a suitable means of analysis for unknown and not commercially available arsenic species. Simultaneous parallel ESI-MS and ICP-MS detection was applied to identify possible metabolites during the interaction of arsenobetaine (AsB) with natural zeolites. AsB, mainly produced by freshwater and marine organisms, is known to be a candidate of low toxicity. To estimate the possible toxicological risk originating from AsB in contact with natural and synthetic zeolites, small particles of a naturally occurring zeolite were mixed with an AsB solution. After a contact time of 56 days the degradation of AsB proceeded with different yields in the case of the natural Mexican zeolites. In contrast, no additional components were detected in the control samples. It was possible to clearly identify the degradation products dimethylarsinate (m/z 139) and dimethylarsinoylacetate (m/z 181) by comparison of the peaks monitored by ESI-MS and ICP-MS. In some other cases the unknown arsenic species could not be identified so clearly from their molecular masses. |
| Databáze: | OpenAIRE |
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