A primate model of human postmenopausal hot flushes
| Autor: | P. Lomax, A. Kappen, E. Schonbaum, J. Jelinek |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Norpregnenes Endocrinology Diabetes and Metabolism Clinical Biochemistry Ethinyl Estradiol Biochemistry Models Biological Clonidine chemistry.chemical_compound Endocrinology Anabolic Agents Internal medicine medicine Animals Castration Climacteric business.industry Naloxone Biochemistry (medical) Thermoregulation medicine.disease Domperidone Menopause medicine.anatomical_structure chemistry Estrogen Scalp Ovariectomized rat Macaca Female business Skin Temperature medicine.drug Body Temperature Regulation |
| Zdroj: | The Journal of clinical endocrinology and metabolism. 59(6) |
| ISSN: | 0021-972X |
| Popis: | The hot flush is the only symptom specifically attributable to the menopause. Hot flushes appear to represent an episodic derangement of thermoregulation as a result of estrogen deficiency but the underlying physiological mechanisms are unknown. We have developed an animal model for the study of hot flushes. Two female monkeys (Macaca arctoides) were trained to accept monitoring of scalp cutaneous temperatures. After baseline temperature recordings were obtained both monkeys were ovariectomized. A few days after operation the previously stable scalp temperature changed to an undulating pattern with cycles lasting approximately 40-50 min. Ethinyl estradiol (20 micrograms orally or im) and (7 alpha,17 alpha)-17-hydroxy-7-methyl-19-nor-pregn-5(10)-en-20-yn-3-one (2.5 mg orally), a steroid with weak estrogenic, progestogenic, and androgenic properties, suppressed the characteristic undulating temperature pattern; this returned after withdrawal of replacement therapy. Clonidine (0.15 mg twice a day) suppressed the cyclic changes for 2 to 3 h. Domperidone and naloxone had no significant effect. This animal model may be useful for the investigation of alternative therapy for the management of menopausal flushes. |
| Databáze: | OpenAIRE |
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