'Grafting to' of RAFTed Responsive Polymers to Glass Substrates by Thiol–Ene and Critical Comparison to Thiol–Gold Coupling
Autor: | Caroline I. Biggs, Marc Walker, Matthew I. Gibson |
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Rok vydání: | 2016 |
Předmět: |
Materials science
Polymers and Plastics Polymers Surface Properties Bioengineering 02 engineering and technology 010402 general chemistry Methacrylate 01 natural sciences Article Polymerization Biomaterials chemistry.chemical_compound Polymer chemistry Materials Chemistry QD Thermoresponsive polymers in chromatography Sulfhydryl Compounds chemistry.chemical_classification Temperature Polymer Quartz Crystal Microbalance Techniques Quartz crystal microbalance Raft 021001 nanoscience & nanotechnology 0104 chemical sciences chemistry Glass Gold 0210 nano-technology Ethylene glycol |
Zdroj: | Biomacromolecules |
ISSN: | 1526-4602 1525-7797 |
Popis: | Surface-grafted polymers have been widely applied to modulate biological interfaces and introduce additional functionality. Polymers derived from reversible addition–fragmentation transfer (RAFT) polymerization have a masked thiol at the ω-chain end providing an anchor point for conjugation and in particular displays high affinity for gold surfaces (both flat and particulate). In this work, we report the direct grafting of RAFTed polymers by a “thiol–ene click” (Michael addition) onto glass substrates rather than gold, which provides a more versatile surface for subsequent array-based applications but retains the simplicity. The immobilization of two thermoresponsive polymers are studied here, poly[oligo(ethylene glycol) methyl ether methacrylate] (pOEGMA) and poly(N-isopropylacrylamide) (pNIPAM). Using a range of surface analysis techniques the grafting efficiency was compared to thiol–gold and was quantitatively compared to the gold alternative using quartz crystal microbalance. It is shown that this method gives easy access to grafted polymer surfaces with pNIPAM resulting in significantly increased surface coverage compared to pOEGMA. The nonfouling (protein resistance) character of these surfaces is also demonstrated. |
Databáze: | OpenAIRE |
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