Minimally important difference of the fatigue severity scale and modified fatigue impact scale in people with multiple sclerosis
Autor: | Leslie Wood, Lorna Paul, Angus McFadyen, Fiona Moffat, Scott Rooney |
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Rok vydání: | 2019 |
Předmět: |
Adult
Male medicine.medical_specialty Multiple Sclerosis Psychometrics Severity of Illness Index 03 medical and health sciences Disability Evaluation 0302 clinical medicine Quality of life medicine Fatigue Severity Scale Humans 030212 general & internal medicine Fatigue business.industry Multiple sclerosis Significant difference Outcome measures Mean age General Medicine Middle Aged medicine.disease Fatigue impact scale Cross-Sectional Studies Neurology Physical therapy Quality of Life Female Neurology (clinical) Ordered logit business 030217 neurology & neurosurgery |
Zdroj: | Multiple sclerosis and related disorders. 35 |
ISSN: | 2211-0356 |
Popis: | Background Fatigue is a common and debilitating symptom of Multiple Sclerosis (MS); however, it is unknown what constitutes a clinically significant change in fatigue. Establishing the minimally important difference (MID) of fatigue outcome measures can inform the interpretation of changes in fatigue by estimating the level of change that is considered clinically relevant. Aim Determine the MID for the Fatigue Severity Scale (FSS) and Modified Fatigue Impact Scale (MFIS) in people with MS. Methods This cross-sectional study collected information on self-reported fatigue (FSS and MFIS) and quality of life (EQ-5D and MS Impact Scale 29) through an online survey. Anchor-based methods were used to estimate MID, and ordinal logistic regression models were used to determine the difference in fatigue that would predict a significant effect on quality of life. Results 365 people with MS (81.9% female, 69.3% relapsing-remitting MS, mean age 46.2 ± 11.6 years, mean time since diagnosis 9.6 ± 8.7 years) responded to the survey. MID estimates for the FSS and MFIS ranged from 0.45–0.88 and 3.86–8.11 respectively, accounting for 6.4–12.6% of maximum FSS score and 4.6–9.7% of maximum MFIS score. Conclusions MID estimates derived from this study indicate that a difference of at least 0.45 points on the FSS or 4 points on the MFIS constitutes a clinically significant difference in fatigue. Therefore, these estimates represent a threshold value which can be used to interpret changes in the FSS and MFIS over time or in response to an intervention. |
Databáze: | OpenAIRE |
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