Metallic Nanoparticles-Friends or Foes in the Battle against Antibiotic-Resistant Bacteria?
| Autor: | Álvaro Morón, Francisco Amaro, Ana Martín-González, Juan Carlos Gutiérrez, Silvia Díaz |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
antibiotic resistance medicine.drug_class Antibiotics Nanotechnology 02 engineering and technology Review 010501 environmental sciences Biology Microbiología 01 natural sciences Microbiology resistance Antibiotic resistance Virology medicine oxidative stress Continuous exposure Metal nanoparticles heavy metals lcsh:QH301-705.5 0105 earth and related environmental sciences Heavy metals 021001 nanoscience & nanotechnology Antimicrobial biology.organism_classification lcsh:Biology (General) nanoparticles 0210 nano-technology Bacteria |
| Zdroj: | E-Prints Complutense: Archivo Institucional de la UCM Universidad Complutense de Madrid Microorganisms, Vol 9, Iss 364, p 364 (2021) Microorganisms E-Prints Complutense. Archivo Institucional de la UCM instname |
| ISSN: | 2076-2607 |
| Popis: | The rapid spread of antibiotic resistances among bacteria demands novel strategies for infection control, and metallic nanoparticles appear as promising tools because of their unique size and tunable properties that allow their antibacterial effects to be maximized. Furthermore, their diverse mechanisms of action towards multiple cell components have suggested that bacteria could not easily develop resistance against nanoparticles. However, research published over the last decade has proven that bacteria can indeed evolve stable resistance mechanisms upon continuous exposure to metallic nanoparticles. In this review, we summarize the currently known individual and collective strategies employed by bacteria to cope with metallic nanoparticles. Importantly, we also discuss the adverse side effects that bacterial exposure to nanoparticles may have on antibiotic resistance dissemination and that might constitute a challenge for the implementation of nanoparticles as antibacterial agents. Overall, studies discussed in this review point out that careful management of these very promising antimicrobials is necessary to preserve their efficacy for infection control. |
| Databáze: | OpenAIRE |
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