Garlic (Allium sativum L.): A Brief Review of Its Antigenotoxic Effects
| Autor: | Eduardo Madrigal-Santillán, María del Carmen Valadez-Vega, Isela Álvarez-González, Manuel Sánchez-Gutiérrez, José A. Morales-González, Ángel Morales-González, Eduardo Madrigal-Bujaidar, Jeannett A. Izquierdo-Vega |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Health (social science)
Sister chromatid exchange Plant Science lcsh:Chemical technology Health Professions (miscellaneous) Microbiology Ames test 03 medical and health sciences garlic 0302 clinical medicine comet assay chromosomal aberrations Medicine micronucleus lcsh:TP1-1185 antigenotoxic potential 030304 developmental biology 0303 health sciences Traditional medicine business.industry Allium sativum 030220 oncology & carcinogenesis sister chromatid exchange business Human cancer Food Science |
| Zdroj: | Foods, Vol 8, Iss 8, p 343 (2019) |
| ISSN: | 2304-8158 |
| Popis: | Traditional Medicine/Complementary and Alternative Medicine is a practice that incorporates medicine based on plants, animals, and minerals for diagnosing, treating, and preventing certain diseases, including chronic degenerative diseases such as obesity, diabetes, hypertension, atherosclerosis, and cancer. Different factors generate its continued acceptance, highlighting its diversity, easy access, low cost, and the presence of relatively few adverse effects and, importantly, a high possibility of discovering antigenotoxic agents. In this regard, it is known that the use of different antigenotoxic agents is an efficient alternative to preventing human cancer and that, in general, these can act by means of a combination of various mechanisms of action and against one or various mutagens and/or carcinogens. Therefore, it is relevant to confirm its usefulness, efficacy, and its spectrum of action through different assays. With this in mind, the present manuscript has as its objective the compilation of different investigations carried out with garlic that have demonstrated its genoprotective capacity, and that have been evaluated by means of five of the most outstanding tests (Ames test, sister chromatid exchange, chromosomal aberrations, micronucleus, and comet assay). Thus, we intend to provide information and bibliographic support to investigators in order for them to broaden their studies on the antigenotoxic spectrum of action of this perennial plant. |
| Databáze: | OpenAIRE |
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