Total pancreatectomy for pancreatic remnant carcinoma five years after pancreaticoduodenectomy: Report a case
| Autor: | Atsushi Takeshita, Masato Ota, Takashi Ishibashi, Kensuke Fujii, Toshikatsu Nitta, Jun Kataoka |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Total pancreatectomy medicine.medical_treatment Case Report Anastomosis Recurrent intraductal papillary mucinous neoplasm 03 medical and health sciences 0302 clinical medicine Pancreatic cancer medicine Carcinoma Mucinous carcinoma business.industry digestive oral and skin physiology medicine.disease Pancreaticoduodenectomy Resection Surgery medicine.anatomical_structure 030220 oncology & carcinogenesis Resection margin Abdomen Adenocarcinoma 030211 gastroenterology & hepatology business |
| Zdroj: | International Journal of Surgery Case Reports |
| ISSN: | 2210-2612 |
| Popis: | Highlights • A 76-year-old Japanese man had invasive intraductal papillary carcinoma (IPMC). • IPMC recurred in the remnant pancreas five years after initial pancreaticoduodenectomy. • Most likely, recurrence was due to multifocal disease that developed a new cyst. • Remnant pancreatectomy is the preferred approach for remnant pancreatic carcinoma due to better median long-term survival outcome. Introduction and importance The prognosis of non-invasive intraductal papillary mucinous neoplasma (IPMN) is better than that of pancreatic cancer. However, if the first surgical finding revealed an invasive IPMC, the risk of recurrence was found to be 7–21%. Case presentation A 76-year-old Japanese man had undergone subtotal stomach-preserving pancreaticoduodenectomy for intraductal papillary mucinous carcinoma non-invasive type at our hospital. No signs of adenocarcinoma at the resection margin were found by pathological examination of frozen sections. Five years later, a blood analysis showed increased serum CA19-9 level. A contrast-enhanced computed tomography scan of the abdomen revealed a mass adjacent to the pancreaticogastrostomy anastomosis. The patient underwent a total pancreatectomy. The tumor was identified as a recurrent IPMC with subserosal invasion, but without nodal involvement. The resection margins were negative. The patient’s postoperative course was uneventful, and he was discharged after 12 days. He is being followed up without adjuvant chemotherapy. Discussion The prognosis of IPMN is better than that of pancreatic cancer. However the risk of recurrence in invasive IPMC was found to be 7–21%. Therefore, IPMC must be surveilled every three months using tumor markers and imaging. Local recurrence in remnant pancreas is usually treated with systemic therapy. The median long-term survival after total pancreatectomy (range 7–24 months) was shown to be better than when chemotherapy alone was used (range 10–13 months). Conclusion We chose secondary surgery in term of survival time although there are quality of life drawbacks that currently make total pancreatectomy more inappropriate in patients than chemotherapy. |
| Databáze: | OpenAIRE |
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