The expression difference of insulin-like growth factor 1 receptor in breast cancers with or without diabetes
| Autor: | Luo Wu-Xia, Qiu Meng, Ding Jing, Tang Jie, Liu Ji-yan, Chen Xin |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
type 2 diabetes mellitus medicine.medical_treatment IGFBP3 Gene Expression Breast Neoplasms lcsh:RC254-282 Receptor IGF Type 1 Insulin-like growth factor Breast cancer Internal medicine Diabetes mellitus Insulin receptor substrate medicine Humans Radiology Nuclear Medicine and imaging Insulin-Like Growth Factor I Neoplasm Metastasis Insulin-like growth factor 1 receptor Aged Neoplasm Staging Retrospective Studies Aged 80 and over biology business.industry human epidermal growth factor receptor 2 Type 2 Diabetes Mellitus General Medicine Middle Aged medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Immunohistochemistry Tumor Burden Insulin receptor Endocrinology Oncology Diabetes Mellitus Type 2 insulin-like growth factor 1 receptor biology.protein Female business Biomarkers Signal Transduction |
| Zdroj: | Journal of Cancer Research and Therapeutics, Vol 11, Iss 2, Pp 295-299 (2015) |
| ISSN: | 1998-4138 |
| Popis: | Context: The insulin-like growth factor (IGF) and insulin receptors' (IR) axes play important roles in both breast cancer and diabetes mellitus. Aim: We tend to explore the expression characteristics of proteins in IGF/IR axis in breast cancer with type 2 diabetes mellitus (T2DM). Settings and Design: We conducted a case-control investigation of T2DM and non-diabetes (n = 40, 1:1) in breast cancer patients. Materials and Methods: Some important molecules of IGF/IR axis were detected in breast cancer tissues by immunohistochemical staining. The multivariable analyses of the relationship of clinicopathological characters with the significant molecules were also detected. Statistical Analysis Used: The results were statistically evaluated by Statistical Package for the Social Sciences (SPSS version 17.0) software. Chi-square test and logistic regression are used. Results: Higher expression of IGF 1 receptor (IGF1R) was found in breast cancers of patients with T2DM, compared those without diabetes (P = 0.044). Negative expression of human epidermal growth factor receptor 2 (Her2) was found to be associated with higher expression of IGF1R in the breast cancers of patients with T2DM. There were no differences found in the expression of proteins of IGF-1, IGF-2, IGF-binding protein 3 (IGFBP3), IR, insulin receptor substrate (IRS)-1, IRS-2 and mammalian target of rapamycin (mTOR) between T2DM group and non-diabetes group. Conclusion: Our study found that breast cancer with T2DM had a higher expression of IGF1R, and the higher IGF1R was associated with negative Her2 expression. |
| Databáze: | OpenAIRE |
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