Electromyographic bursting following the cortical silent period induced by transcranial magnetic stimulation
| Autor: | Olivia Chin, Robin F.H. Cash, Gary Thickbroom |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_treatment Biophysics Electromyography Stimulus (physiology) Inhibitory postsynaptic potential Young Adult Bursting medicine Humans Muscle Skeletal Molecular Biology medicine.diagnostic_test business.industry General Neuroscience Cortical Spreading Depression Motor Cortex Evoked Potentials Motor Transcranial Magnetic Stimulation Electric Stimulation Transcranial magnetic stimulation medicine.anatomical_structure Cortical spreading depression Female Silent period Neurology (clinical) business Neuroscience Developmental Biology Motor cortex |
| Zdroj: | Brain Research. 1446:40-45 |
| ISSN: | 0006-8993 |
| Popis: | In subjects performing voluntary background contraction, transcranial magnetic stimulation (TMS) induces an interruption of electromyographic (EMG) activity known as the silent period (SP). This is thought to be mediated through the action of inhibitory cortical neurons, in particular involving γ-aminobutyric acid type B (GABA(B)) receptors. In some studies of the SP, a post-SP increase in EMG activity has been reported but not described in detail. In the present study we have sought to determine the presence and persistence of late EMG bursting associated with the return of voluntary drive after the SP, and to characterize the relationship to background contraction level, stimulus intensity, and SP duration. TMS was delivered at 3 levels of intensity (120, 140 and 160% of active motor threshold) and during 3 levels of voluntary contraction of the first dorsal interosseous muscle (10, 30 and 50% of maximum contraction) in a pseudo-randomized order in 11 healthy participants. The SP was followed by a brief (~60 ms) burst of EMG up to 290±42% of the pre-stimulus EMG level. Both SP duration and the amplitude of the EMG burst increased with TMS intensity (p |
| Databáze: | OpenAIRE |
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