Enantioselective S−H Insertion Reactions of α‐Carbonyl Sulfoxonium Ylides

Autor:	Matthew N. Grayson, Patrícia B. Momo, Antonio C. B. Burtoloso, Anita E. Mattson, Elliot H. E. Farrar, Alexandria N. Leveille
Rok vydání:	2020
Předmět:	Organocatalysis Communication Aryl Enantioselective synthesis REAGENTES General Chemistry General Medicine S−H insertion Medicinal chemistry Communications Catalysis chemistry.chemical_compound Thiourea chemistry sulfoxonium ylide enantioselectivity aryl thiol
Zdroj:	Angewandte Chemie (International Ed. in English) Momo, P B, Leveille, A N, Farrar, E H E, Grayson, M N, Mattson, A E & Burtoloso, A C B 2020, ' Enantioselective S-H Insertion Reactions of α-Carbonyl Sulfoxonium Ylides ', Angewandte Chemie-International Edition, vol. 59, no. 36, pp. 15554-15559 . https://doi.org/10.1002/anie.202005563 Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP
ISSN:	1521-3757 0044-8249
Popis:	The first example of enantioselective S−H insertion reactions of sulfoxonium ylides is reported. Under the influence of thiourea catalysis, excellent levels of enantiocontrol (up to 95 % ee) and yields (up to 97 %) are achieved for 31 examples in S−H insertion reactions of aryl thiols and α‐carbonyl sulfoxonium ylides. The first enantioselective S−H insertion reaction of α‐carbonyl sulfoxonium ylides was developed under thiourea catalysis. Up to 95 % ee and 97 % isolated yields were obtained in 31 examples.
Databáze:	OpenAIRE
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