Growth, Protein and Energy Intake in Children with PKU Taking a Weaning Protein Substitute in the First Two Years of Life: A Case-Control Study

Autor: S Chahal, Anne Daly, Nik Loveridge, Sharon Evans, Catherine Ashmore, Anita MacDonald, J. Wildgoose, Barbara Cochrane
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
Male
Longitudinal study
congenital
hereditary
and neonatal diseases and abnormalities
Cephalometry
growth
lcsh:TX341-641
030209 endocrinology & metabolism
Phenylketonuria (PKU)
Energy requirement
Article
03 medical and health sciences
0302 clinical medicine
Animal science
Phenylketonurias
medicine
Weaning
Humans
Longitudinal Studies
Prospective Studies
Prospective cohort study
030109 nutrition & dietetics
Nutrition and Dietetics
business.industry
weaning
Significant difference
Body Weight
Case-control study
nutritional and metabolic diseases
Infant
Nutrients
medicine.disease
Body Height
Case-Control Studies
Child
Preschool
Dietary Supplements
Female
Dietary Proteins
business
protein substitute
Energy Intake
lcsh:Nutrition. Foods and food supply
Body mass index
Head
Food Science
Zdroj: Nutrients
Volume 11
Issue 3
Nutrients, Vol 11, Iss 3, p 552 (2019)
ISSN: 2072-6643
Popis: Growth issues have been observed in young children with phenylketonuria (PKU), but studies are conflicting. In infancy, there is an increasing trend to introduce a second-stage semi-solid weaning protein substitute (WPS) but there is concern that this may not meet energy requirements. In this longitudinal, prospective study, 20 children with PKU transitioning to a WPS, and 20 non-PKU controls were observed monthly from weaning commencement (4&ndash
6 months) to 12 m and at 15, 18 and 24 months of age for: weight, length, head circumference, body mass index (BMI), energy and macronutrient intake. Growth parameters were within normal range at all ages in both groups with no significant difference in mean z-scores except for accelerated length in the PKU group. No child with PKU had z-scores <
&minus
2 for any growth parameter at age 2 years. Total protein and energy intake in both groups were similar at all ages
however, from 12&ndash
24 months in the PKU group, the percentage of energy intake from carbohydrate increased (60%) but from fat decreased (25%) and inversely for controls (48% and 36%). In PKU, use of low volume WPS meets Phe-free protein requirements, facilitates transition to solid foods and supports normal growth. Further longitudinal study of growth, body composition and energy/nutrient intakes in early childhood are required to identify any changing trends.
Databáze: OpenAIRE
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