Improved kidney function with cilazapril in hypertensive type II diabetics with chronic renal failure
| Autor: | Drori Ben-Ishay, Isaac Kobrin, Joseph Fidel, Michael Bursztyn |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
medicine.medical_specialty Hypertension Renal Urinary system Urology Renal function Angiotensin-Converting Enzyme Inhibitors Blood Pressure Cilazapril Kidney Kidney Function Tests chemistry.chemical_compound Heart Rate Internal medicine Heart rate Medicine Humans Diabetic Nephropathies Aged Pharmacology Creatinine biology business.industry Angiotensin-converting enzyme Middle Aged Pyridazines Blood pressure Endocrinology medicine.anatomical_structure chemistry Diabetes Mellitus Type 2 biology.protein Kidney Failure Chronic Female Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Journal of cardiovascular pharmacology. 18(3) |
| ISSN: | 0160-2446 |
| Popis: | The purpose of this study was to determine efficacy and safety of the angiotensin converting enzyme inhibitor, cilazapril, in the treatment of hypertensive diabetics with renal insufficiency. Fifteen type II diabetics with hypertension and chronic renal insufficiency aged (mean +/- SD) 64 +/- 7 years were studied in a regional clinic and university hospital hypertension unit. The blood pressure was measured biweekly. Urinary collections were done after 2 weeks of placebo and 8 weeks of cilazapril treatment. The blood pressure decreased from 176 +/- 15/105 +/- 9 to 164 +/- 11/95 +/- 9 mm Hg and serum creatinine from 197 +/- 69 to 179 +/- 73 mumol/L. The creatinine clearance rose from 41.6 +/- 11.4 to 47.4 +/- 14.9 ml/min, while protein excretion decreased from 0.8 +/- 1.3 to 0.5 +/- 0.8 g/24 h (p less than 0.05). The blood pressure change was inversely correlated with the creatinine clearance change (r = -0.5, n = 15, p less than 0.05). In these high-risk patients, 8 weeks of cilazapril treatment improved both blood pressure control and renal function but renal function improved most in the patients whose blood pressure changed the least. |
| Databáze: | OpenAIRE |
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