Maternal Administration of the Herbal Medicine Toki-Shakuyaku-San Promotes Fetal Growth and Placental Gene Expression in Normal Mice
| Autor: | Heng Li, Keiji Wada, Etsuko Wada |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Litter (animal)
medicine.medical_specialty genetic structures Placenta medicine.medical_treatment Gene Expression Biology Fetal Development Mice Fetus Insulin-Like Growth Factor II Pregnancy Reference Values Internal medicine Gene expression medicine Animals Gene reproductive and urinary physiology Growth factor Biological Transport Transporter General Medicine bacterial infections and mycoses Placentation Mice Inbred C57BL Endocrinology medicine.anatomical_structure Fetal Weight Complementary and alternative medicine embryonic structures Embryo Loss Gestation Female Drugs Chinese Herbal |
| Zdroj: | The American Journal of Chinese Medicine. 41:515-529 |
| ISSN: | 1793-6853 0192-415X |
| Popis: | Toki-shakuyaku-san (TSS), an herbal formula based on traditional Chinese medicine, is commonly used in obstetrics. To examine the effects of TSS on the normal mouse fetus and placenta, TSS was administered to normal pregnant mice and their placentas and fetuses were studied. First, the effects of maternal TSS treatment on implantation were investigated. Administration of TSS from gestation day 0.5 (G0.5) to G6.5 showed that litter size was not altered at embryonic day 11.5 (E11.5), but the number of resorbed fetuses was slightly decreased. Then, to investigate effects on fetal and placental growths after implantation, TSS was administered from G5.5. At E14.5, the body weight of fetuses from TSS-treated dams was significantly increased. Gene expression of insulin-like growth factor 2 (Igf2), one of the most important modulators of fetal growth, was significantly increased in the placentas and fetuses of TSS-treated dams. In addition, the expression of particular placental developmental genes and nutrient transporter genes was significantly increased in TSS-treated placentas. At E18.5, after longer-term administration of TSS, fetal and placental weights were not altered, but the expression of the placental developmental and nutrient transporter genes remained elevated compared with controls. These results suggest that maternal TSS treatment in normal mice enhances the expression of Igf2, placental developmental genes and nutrient transporter genes, resulting in increased fetal weight. No obvious changes were observed in the expression of these genes after longer-term maternal TSS treatment. |
| Databáze: | OpenAIRE |
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