Two New Cytotoxic Linderazulenes from a Deep-Sea Gorgonian of the Genus Paramuricea
| Autor: | Longley Re, John K. Reed, Reddy Ns, Amy E. Wright |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
food.ingredient
Pharmaceutical Science Antineoplastic Agents Biology Azulenes Analytical Chemistry Cnidaria Inhibitory Concentration 50 Paramuricea food Genus Cell Line Tumor Drug Discovery Animals Cytotoxic T cell Furans Cytotoxicity Nuclear Magnetic Resonance Biomolecular Pharmacology Molecular Structure Leukemia P388 Organic Chemistry Biological activity Anatomy biology.organism_classification Molecular biology In vitro Gorgonian Complementary and alternative medicine Cell culture Molecular Medicine Drug Screening Assays Antitumor |
| Zdroj: | Journal of Natural Products. 68:248-250 |
| ISSN: | 1520-6025 0163-3864 |
| Popis: | The known compound linderazulene (1) and two new linderazulenes (2, 3) were isolated from a deep-sea gorgonian Paramuricea sp. The structures of 2 and 3 were determined through spectroscopic methods. Compounds 1-3 show moderate in vitro cytotoxicity against the P388 murine leukemia cell line with IC(50)'s of 18.8, 2.7, and 15.6 microg/mL, respectively. Compound 2 showed moderate activity against the PANC-1 pancreatic cell line with an IC(50) of 18.7 microg/mL. |
| Databáze: | OpenAIRE |
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