Comparison of the efficacy of 0.03% tacrolimus eye drops diluted in olive oil and linseed oil for the treatment of keratoconjunctivitis sicca in dogs
| Autor: | Aline Gutierrez Cruz, Carolina Silva Guimarães Pereira, Bruna Toledo Duran Foglia, Silvia Franco Andrade, Luís Felipe da Costa Zulim, Hugo Benguella, Rogério Giuffrida, Aline da Silveira Batista, Gisele Alborgetti Nai |
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| Jazyk: | angličtina |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty food.ingredient Administration Ophthalmic Gastroenterology Tacrolimus 03 medical and health sciences chemistry.chemical_compound food Dogs Linseed oil lcsh:Ophthalmology Internal medicine Medicine KERATOCONJUNCTIVITIS SICCA Animals Fluorescein Goblet cell business.industry Ophthalmic solutions General Medicine Keratoconjunctivitis sicca eye diseases Ophthalmology 030104 developmental biology medicine.anatomical_structure Treatment Outcome chemistry lcsh:RE1-994 Absolute neutrophil count Decreased lymphocytes Drug Therapy Combination Female business Immunosuppressive Agents Olive oil |
| Zdroj: | Arquivos Brasileiros de Oftalmologia, Vol 81, Iss 4, Pp 293-301 Arquivos Brasileiros de Oftalmologia v.81 n.4 2018 Arquivos brasileiros de oftalmologia Conselho Brasileiro de Oftalmologia (CBO) instacron:CBO |
| ISSN: | 1678-2925 |
| Popis: | Objective: To compare the efficacy of 0.03% tacrolimus eye drops diluted in two different vehicles (linseed oil and olive oil) for the treatment of keratoconjunctivitis sicca (KCS) in dogs. Methods: This study included 60 dogs. Of this group, 20 were healthy and allocated to the control group, and 40 were diagnosed with bilateral KCS and randomly allocated to either the TO (tacrolimus in olive oil) or the TL (tacrolimus in linseed oil) groups. Ophthalmic examinations, Schirmer Tear Test-1 (STT-1), Tear Film Break-up Time (TBUT) and Fluorescein Test (FT) were carried out monthly, along with cytological and histopathological examinations at the beginning and end of the study. Results: The clinical signs, corneal ulcers, Schirmer Tear Test-1 values, and Tear Film Break-up Time values improved in both groups after one month of treatment. Cytological examination at the end of the study showed decreased lymphocytes, neutrophil, metaplastic, and squamous cell counts in both groups, while the histopathological analysis showed decreases in lymphocytes and neutrophils and an increase in goblet cell density (cells/mm2). The decreases in neutrophil count were more significant (p |
| Databáze: | OpenAIRE |
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