Assessment of primary liver carcinomas other than hepatocellular carcinoma (HCC) with LI-RADS v2018: comparison of the LI-RADS target population to patients without LI-RADS-defined HCC risk factors
| Autor: | Allan Tsung, Anup S. Shetty, Richard Tsai, Amir A. Borhani, Kathryn J. Fowler, Maverick LeBlanc, Tyler J. Fraum, Daniel R. Ludwig, Alessandro Furlan, Amber Salter, Muhammad Naeem, Roberto Cannella |
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| Přispěvatelé: | Fraum T.J., Cannella R., Ludwig D.R., Tsai R., Naeem M., LeBlanc M., Salter A., Tsung A., Shetty A.S., Borhani A.A., Furlan A., Fowler K.J. |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Carcinoma Hepatocellular Contrast Media Target population Logistic regression Gastroenterology Liver neoplasm 030218 nuclear medicine & medical imaging Liver cirrhosi Diagnosis Differential Cholangiocarcinoma 03 medical and health sciences 0302 clinical medicine hepatocellular Risk Factors Internal medicine Bile duct neoplasm Humans Medicine Single-Blind Method Radiology Nuclear Medicine and imaging Aged Retrospective Studies Neuroradiology medicine.diagnostic_test business.industry Liver Neoplasms Carcinoma Retrospective cohort study Interventional radiology General Medicine Middle Aged medicine.disease Magnetic Resonance Imaging digestive system diseases Exact test Logistic Models 030220 oncology & carcinogenesis Hepatocellular carcinoma Female Radiology Tomography X-Ray Computed business Settore MED/36 - Diagnostica Per Immagini E Radioterapia Arterial phase |
| Popis: | To determine whether the LI-RADS imaging features of primary liver carcinomas (PLCs) other than hepatocellular carcinoma (non-HCC PLCs) differ between patients considered high risk (RF+) versus not high risk (RF−) for HCC and to compare rates of miscategorization as probable or definite HCC between the RF+ and RF− populations. This retrospective study included all pathology-proven non-HCC PLCs imaged with liver-protocol CT or MRI from 2007 to 2017 at two liver transplant centers. Patients were defined per LI-RADS v2018 criteria as RF+ or RF−. Two independent, blinded readers (R1, R2) categorized 265 lesions using LI-RADS v2018. Logistic regression was utilized to assess for differences in imaging feature frequencies between RF+ and RF− patients. Fisher’s exact test was used to assess for differences in miscategorization rates. Non-HCC PLCs were significantly more likely to exhibit nonrim arterial phase hyperenhancement (R1: OR = 2.94; R2: OR = 7.09) and nonperipheral “washout” (R1: OR = 3.65; R2: OR = 7.69) but significantly less likely to exhibit peripheral “washout” (R1: OR = 0.30; R2: OR = 0.10) and delayed central enhancement (R1: OR = 0.18; R2: OR = 0.25) in RF+ patients relative to RF− patients. Consequently, non-HCC PLCs were more often miscategorized as probable or definite HCC in RF+ versus RF− patients (R1: 23.3% vs. 3.6%, p |
| Databáze: | OpenAIRE |
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