Dietary aflatoxin B1 intake, genetic polymorphisms of CYP1A2, CYP2E1, EPHX1, GSTM1, and GSTT1, and gastric cancer risk in Korean
| Autor: | Young-Jin Song, Sang-Yong Eom, Byung Sik Kim, Sei-Jin Youn, Dong-Hyuk Yim, yanwei Zhang, Joo-Seung Park, Heon Kim, Sun In Moon, Taisun Hyun, Hyo-Yung Yun, Yong-Dae Kim, Jong-Young Lee, Jung-Kuk Yun |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Cancer Research Aflatoxin medicine.medical_specialty Aflatoxin B1 Genotype Physiology EPHX1 Polymorphism Single Nucleotide Poisons Asian People Gene Frequency Cytochrome P-450 CYP1A2 Risk Factors Stomach Neoplasms Epidemiology Republic of Korea Odds Ratio Medicine Humans Aged Glutathione Transferase Epoxide Hydrolases biology business.industry CYP1A2 Cancer Cytochrome P-450 CYP2E1 CYP2E1 Middle Aged medicine.disease Health Surveys Glutathione S-transferase Oncology Case-Control Studies biology.protein Female business Cancer risk |
| Zdroj: | Cancer causescontrol : CCC. 24(11) |
| ISSN: | 1573-7225 |
| Popis: | We investigated the effects of aflatoxin B1 (AFB1) intake, genetic polymorphisms of AFB1 metabolic enzymes, and interactions between the polymorphisms and intake of AFB1 with regard to the risk of gastric cancer in Korean.The participants in the study included 477 gastric cancer patients and 477 age- and sex-matched control subjects. Direct interviews and a structured questionnaire were used to determine the level of exposure to AFB1, and the GoldenGate assay and multiplex polymerase chain reaction were used for genotypic analyses of the cytochrome P450 1A2 (CYP1A2), cytochrome P450 1E1, epoxide hydrolase 1, and glutathione S-transferase genes.The probable daily intake of AFB1 was significantly higher among gastric cancer patients than among control subjects (cases vs. controls: 1.91 ± 0.87 vs. 1.65 ± 0.72 ng/kg bw/day, p0.0001), and increased AFB1 intake was significantly associated with an elevated risk of gastric cancer (odds ratio 1.94; 95 % confidence interval 1.43-2.63). However, genetic polymorphisms of AFB1 metabolic enzymes were not associated with gastric cancer, with the exception of CYP1A2. Moreover, there was no interaction between AFB1 intake and the genotypes of metabolic enzymes that affect gastric cancer risk.Our results suggest that dietary AFB1 exposure might be associated with a risk of gastric cancer. However, the effect of AFB1 on gastric carcinogenesis may not be modulated by genetic polymorphisms of AFB1 metabolic enzymes. |
| Databáze: | OpenAIRE |
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