Impact of chronic variable stress on neuroendocrine hypothalamus and pituitary in male and female C57BL/6J mice

Autor: Gregory T. Bouwer, Greg M. Anderson, Allan E. Herbison, David R. Grattan, Melanie Prescott, Danielle E. Jenkins, Robert Porteous, Karl J. Iremonger, Siew Hoong Yip, Rebecca Campbell, Kelly A. Glendining, Colin H. Brown, Christine L. Jasoni, Zin Khant Aung, Mauro S.B. Silva, Stephen J. Bunn, Betina B. Nair, Rachael A. Augustine
Rok vydání: 2021
Předmět:
Male
Hypothalamo-Hypophyseal System
endocrine system
medicine.medical_specialty
Pro-Opiomelanocortin
Endocrinology
Diabetes and Metabolism
Hypothalamus
Pituitary-Adrenal System
Thyrotropin
030209 endocrinology & metabolism
Biology
FSHB
Mice
03 medical and health sciences
Cellular and Molecular Neuroscience
chemistry.chemical_compound
fluids and secretions
0302 clinical medicine
Endocrinology
Ovarian Follicle
Corpus Luteum
Corticosterone
Posterior pituitary
Internal medicine
medicine
Animals
Endocrine system
Chronic stress
Neurons
Endocrine and Autonomic Systems
Luteinizing Hormone
equipment and supplies
Prolactin
medicine.anatomical_structure
chemistry
Growth Hormone
Pituitary Gland
Female
Stress
Psychological
hormones
hormone substitutes
and hormone antagonists
030217 neurology & neurosurgery
Hormone
Zdroj: Journal of Neuroendocrinology. 33
ISSN: 1365-2826
0953-8194
Popis: Chronic stress exerts multiple negative effects on the physiology and health of an individual. In the present study, we examined hypothalamic, pituitary and endocrine responses to 14 days of chronic variable stress (CVS) in male and female C57BL/6J mice. In both sexes, CVS induced a significant decrease in body weight and enhanced the acute corticosterone stress response, which was accompanied by a reduction in thymus weight only in females. However, single-point blood measurements of basal prolactin, thyroid-stimulating hormone, luteinising hormone, growth hormone and corticosterone levels taken at the end of the CVS were not different from those of controls. Similarly, pituitary mRNA expression of Fshb, Lhb, Prl and Gh was unchanged by CVS, although Pomc and Tsh were significantly elevated. Within the adrenal medulla, mRNA for Th, Vip and Gal were elevated following CVS. Avp transcript levels within the paraventricular nucleus of the hypothalamus were increased by CVS; however, levels of Gnrh1, Crh, Oxt, Sst, Trh, Ghrh, Th and Kiss1 remained unchanged. Oestrous cycles were lengthened slightly by CVS and ovarian histology revealed a reduction in the number of preovulatory follicles and corpora lutea. Taken together, these observations indicate that 14 days of CVS induces an up-regulation of the neuroendocrine stress axis and creates a mild disruption of female reproductive function. However, the lack of changes in other neuroendocrine axes controlling anterior and posterior pituitary secretion suggest that most neuroendocrine axes are relatively resilient to CVS.
Databáze: OpenAIRE
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