Systematic Literature Review and Network Meta-analysis of the Efficacy and Acceptability of Interventions in Actinic Keratoses
| Autor: | M. Brignone, Caroline Painchault, Khaled Ezzedine |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Ingenol mebutate Psychological intervention Imiquimod Dermatology law.invention chemistry.chemical_compound Methyl aminolevulinate Randomized controlled trial law medicine actinic keratosis Humans network meta-analysis business.industry Actinic keratosis systematic literature review General Medicine medicine.disease Keratosis Actinic Treatment Outcome Systematic review Photochemotherapy chemistry field-directed intervention Meta-analysis RL1-803 Diterpenes business medicine.drug |
| Zdroj: | Acta Dermato-Venereologica, Vol 101, Iss 1, p adv00358 (2021) |
| ISSN: | 1651-2057 0001-5555 |
| Popis: | A systematic literature review was conducted to identify and qualitatively assess randomized controlled trials in immunocompetent patients ≥ 18 years with head- region lesions of actinic keratoses who were treated with field-directed, lesion-directed and other therapies. Network meta-analysis was used to quantitatively evaluate field-directed therapies (5-fluorouracil formulations, diclofenac sodium, imiquimod, ingenol mebutate, 5-aminolevulinic acid or methyl aminolevulinate plus photodynamic therapy) using complete clearance or partial clearance of actinic keratoses lesions, and adverse event-related withdrawals as a proxy of acceptability. Of 2,863 references identified, 75 trials reported in 151 publications were included. In summary, comparative network meta-analysis evaluation showed that 5-fluorouracil formulations were the most efficacious interventions examined. 5-fluorouracil 4%, which was recently approved, showed a comparable efficacy profile to 5-fluorouracil 5%, and had satisfactory acceptability outcomes. |
| Databáze: | OpenAIRE |
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