Tiny Bodies, Big Needs: Prospective Biobanking of Neonatal Clinical Remnant Samples
Autor: | Bryan Lopes, Frances Hamblin, Sandra Brooks, Allen D. Everett, Jennifer Ross-Wilkinson, Christy Fernald, Jennifer Cross, Austin Sellers, Ernest M. Graham, Hector Monforte, Robert Follett, Denise Martinez, William Schleif |
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Rok vydání: | 2021 |
Předmět: |
Parents
medicine.medical_specialty Medicine (miscellaneous) General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Intensive Care Units Neonatal medicine Humans Prospective Studies Intensive care medicine Repurposing Biological Specimen Banks 030219 obstetrics & reproductive medicine business.industry Infant Newborn 0402 animal and dairy science Original Articles 04 agricultural and veterinary sciences Cell Biology General Medicine Phlebotomy 040201 dairy & animal science Biobank Biomarker business Infant Premature |
Zdroj: | Biopreserv Biobank |
ISSN: | 1947-5543 1947-5535 |
Popis: | Repurposing biological samples collected for required diagnostic purposes into suitable biobanking projects is a particularly useful method for enabling research in vulnerable populations. This approach is especially appropriate for the neonate in the neonatal intensive care unit (NICU), where blood volume reductions can quickly increase beyond minimal risk for adverse events, such as iatrogenic anemia, and proxy consent provided by parents or guardians is required. The method described in this study provides a framework to prospectively collect and store blood-derived clinical samples after all clinical and regulatory requirements are fulfilled. The consent approach incorporated a 30-day window to allow parents and guardians ample consideration time with follow-up involvement with NICU embedded study team members. The study enrolled 875 participants over a 3-year period. This established a critically needed biobank to support investigator-initiated research with explicit study aims requiring samples at defined day of life frequencies within the NICU and created a normative control reference bank for case comparisons for premature and full-term neonates with brain injury. |
Databáze: | OpenAIRE |
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