Effect of 3'-azido-3'-deoxythymidine on replication of duck hepatitis B virus in vivo and in vitro
| Autor: | Toshikazu Uchida, Hideaki Haritani, Toshio Shikata, Yasunori Okuda |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
DNA Replication
Hepatitis B virus viruses Duck hepatitis B virus medicine.disease_cause Virus Replication digestive system Duck hepatitis virus Virus Hepatitis B Virus Duck Zidovudine chemistry.chemical_compound Virology medicine Animals heterocyclic compounds Cells Cultured Enterovirus biology Dose-Response Relationship Drug virus diseases biochemical phenomena metabolism and nutrition biology.organism_classification Molecular biology Reverse transcriptase Infectious Diseases Ducks chemistry Hepadnaviridae DNA Viral DNA medicine.drug |
| Zdroj: | Journal of medical virology. 29(4) |
| ISSN: | 0146-6615 |
| Popis: | 3'-Azido-3'-deoxythymidine (AZT) inhibits the replication of the human immunodeficiency virus (HIV) by blocking the formation of the phosphodiester bond and has been used clinically for the treatment of HIV infection. To assess the effect of AZT on the replication of hepadnaviruses, which replicate through reverse transcription, both the liver tissue and primary cultured hepatocytes from ducklings previously infected with duck hepatitis B virus (DHBV) were examined for DHBV DNA before and after the treatment with AZT. We did not observe suppression of DHBV replication at any doses in our system as measured by viral DNA synthesis in infected duck hepatocytes. The data strongly suggest that AZT has no inhibitory effect on DHBV reverse transcriptase. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text