Determination of the antimicrobial susceptibility pattern of extended spectrum beta lactamase (esbl) producing and the non-esbl producing strains of Escherichia coli
| Autor: | Patrick Nguku, GB Gadzama, Mahmoud M Dalhat, Aisha Abubakar, SB Zailani, Yahaya Mohammed, U Bajoga, AA Olufemi, Baffa Sule Ibrahim |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Imipenem biology medicine.drug_class General Chemical Engineering medicine.medical_treatment 030106 microbiology Cephalosporin Antibiotics biochemical phenomena metabolism and nutrition bacterial infections and mycoses Antimicrobial biology.organism_classification medicine.disease_cause Microbiology 03 medical and health sciences Escherichia polycyclic compounds Beta-lactamase medicine bacteria Agar diffusion test Escherichia coli Cephalosporins Resistance Maiduguri Nigeria medicine.drug |
| Zdroj: | African Journal of Clinical and Experimental Microbiology; Vol 17, No 2 (2016); 125-129 |
| ISSN: | 1595-689X |
| Popis: | Background: The extended spectrum beta lactamases producing bacteria are bacteria of great concern among Gram negative bacilli. Escherichia coli stand out as major carrier of this enzyme. The appropriate control of this resistance pattern depends on using the antimicrobial regimen of best choice. Therefore the value of the susceptibility profile of organism harboring this enzyme cannot be overemphasized. Objectives: To determine the antimicrobial susceptibility of extended spectrum beta lactamases (ESBL) producing and the non-ESBL producing strains of Escherichia coli from clinical isolates of Escherichia coli in University of Maiduguri Teaching Hospital. Methodology: Confirmed variants of Escherichia coli were screened and confirmed for ESBL possession. Subsequently, modified Kirby Bauer method was utilized to test for antibiotic susceptibility using the commercially available Oxoid single disc for some major antibiotics. Results: A total of 172 strains of Escherichia coli were identified during the study period. Out of this number; 131 were identified as ESBL positive while a total of 41 were ESBL negative. The highest sensitivity for both the ESBL positive and ESBL negative strains of Escherichia coli was observed with Imipenem followed closely by Gentamicin. Conclusion : The study reveals narrow choice of antibiotics for the ESBL positive isolates of Escherichia coli although Imipenem antibiotic still retains its sensitivity. Keywords: Cephalosporins, Resistance, Maiduguri, Nigeria |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|