Utility of coronal contrast-enhanced fat-suppressed FLAIR in the evaluation of optic neuropathy and atrophy
Autor: | Alexander M. McKinney, Veena R. Iyer, Kevin H. Boegel, Jeffrey B. Rykken, Andrew E. Tyan |
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Rok vydání: | 2017 |
Předmět: |
lcsh:Medical physics. Medical radiology. Nuclear medicine
Pathology medicine.medical_specialty genetic structures CE Contrast-Enhanced lcsh:R895-920 media_common.quotation_subject CE-FS-FLAIR Contrast-Enhanced Fat-Suppressed FLAIR Optic neuritis Fluid-attenuated inversion recovery Optic neuropathy Article 030218 nuclear medicine & medical imaging Multiple sclerosis 03 medical and health sciences 0302 clinical medicine Atrophy Pptic nerve atrophy medicine Contrast (vision) Radiology Nuclear Medicine and imaging FS Fat-Suppressed media_common business.industry Optic nerve atrophy medicine.disease eye diseases CE-T1WI Contrast-Enhanced T1WI Coronal plane Contrast-enhanced fat-suppressed FLAIR sense organs Radiology business 030217 neurology & neurosurgery |
Zdroj: | European Journal of Radiology Open European Journal of Radiology Open, Vol 4, Iss, Pp 13-18 (2017) |
ISSN: | 2352-0477 |
DOI: | 10.1016/j.ejro.2017.02.002 |
Popis: | Background and purpose: Evaluating chronic sequelae of optic neuritis, such as optic neuropathy with or without optic nerve atrophy, can be challenging on whole brain MRI. This study evaluated the utility of dedicated coronal contrast-enhanced fat-suppressed FLAIR (CE-FS-FLAIR) MR imaging to detect optic neuropathy and optic nerve atrophy. Materials and methods: Over 4.5 years, a 3 mm coronal CE-FS-FLAIR sequence at 1.5T was added to the routine brain MRIs of 124 consecutive patients, 102 of whom had suspected or known demyelinating disease. Retrospective record reviews confirmed that 28 of these 102 had documented onset of optic neuritis >4 weeks prior to the brain MRI. These 28 were compared to the other 22 (âcontrolsâ) of the 124 patients who lacked a history of demyelinating disease or visual symptoms. Using coronal CE-FS-FLAIR, two neuroradiologists separately graded each optic nerve (n = 50 patients, 100 total nerves) as either negative, equivocal, or positive for optic neuropathy or atrophy. The scoring was later repeated. Results: The mean time from acute optic neuritis onset to MRI was 4.1 ± 4.6 years (range 34 days-17.4 years). Per individual nerve grading, the range of sensitivity, specificity, and accuracy of coronal CE-FS-FLAIR in detecting optic neuropathy was 71.4â77.1%, 93.8â95.4%, and 85.5â89.0%, respectively, with strong interobserver (k = 0.667 â 0.678, p |
Databáze: | OpenAIRE |
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