Three-Point Association of HLA-A,B,Bf Haplotypes Deduced in 200 Parents of 100 Families

Autor:	B. Kuntz, E. D. Albert, C. Rittner, S. Scholz, M. R. Mickey
Rok vydání:	1977
Předmět:	Adult Male Genetics Linkage disequilibrium Genotype Genetic Linkage Histocompatibility Testing Immunology Haplotype General Medicine Haploidy Biology Phenotype HLA-A Antigen HLA Antigens Histocompatibility Antigens Humans Female Allele Child Caucasian population
Zdroj:	Scandinavian Journal of Immunology. 6:459-464
ISSN:	1365-3083 0300-9475
DOI:	10.1111/j.1365-3083.1977.tb02103.x
Popis:	The association of HLA-A and -B antigens with Bf alleles was investigated in 200 parents from 100 unrelated families. There were significant associations between HLA-A3 and Bf-F, B7 and Bf-S, B8 and Bf-S, B12 and Bf-F, and BW 35 and Bf-F. Three-point HLA-A,B,Bf haplotype frequencies, linkage disequilibrium parameters, and chi-square values were determined both from the genotype and from the phenotype data. Although the HLA-B,Bf associations involve antigens that are also present in the highly associated A,B and B,D haplotypes of the Caucasian population, there was--with the possible exception of HLA-A3,B7,Bf-S--no significant three-point association for HLA-A,B,Bf.
Databáze:	OpenAIRE
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