Sex disparities in outcomes among adults on long-term antiretroviral treatment in northern Nigeria
| Autor: | Muktar H. Aliyu, Melynda Simmons, Ibrahim Nashabaru, Musa A. Garbati, Daiyabu A. Ibrahim, Baba Maiyaki Musa, Aisha M. Nalado, Shehu M Yusuf |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine Time Factors Health (social science) Adolescent Anti-HIV Agents Treatment outcome Nigeria HIV Infections Cohort Studies Young Adult 03 medical and health sciences Sex Factors 0302 clinical medicine Antiretroviral treatment Humans Medicine 030212 general & internal medicine Young adult Generalized estimating equation Aged Retrospective Studies Aged 80 and over business.industry Confounding Public Health Environmental and Occupational Health Retrospective cohort study Original Articles General Medicine Middle Aged 030112 virology Treatment Outcome Africa Immunology Female business Demography Cohort study Sex characteristics |
| Zdroj: | International Health. 9:3-10 |
| ISSN: | 1876-3405 1876-3413 |
| Popis: | BACKGROUND There are conflicting reports of sex differences in HIV treatment outcomes in Africa. We investigated sex disparities in treatment outcomes for adults on first line antiretroviral treatment (ART) in Nigeria. METHODS We compared clinical and immunologic responses to ART between HIV-infected men (n=205) and women (n=140) enrolled in an ART program between June 2004 and December 2007, with follow-up through June 2014. We employed Kaplan-Meier estimates to examine differences in time to immunologic failure and loss to follow-up (LTFU), and generalized estimating equations to assess changes in CD4+ count by sex. RESULTS Men had lower baseline mean CD4+ count compared to women (327.6 cells/µL vs 413.4, respectively, p |
| Databáze: | OpenAIRE |
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