Anti-inflammatory effects of vitamin E on experimental lens-induced uveitis
| Autor: | Alex Sevanian, Narsing A. Rao, Geeta Pararajasegaram, Lilet Cid, George E. Marak, Jorge L. Romero, William Gauderman |
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| Rok vydání: | 1992 |
| Předmět: |
Vitamin
medicine.medical_specialty Normal diet medicine.drug_class medicine.medical_treatment Radioimmunoassay Anti-inflammatory Uveitis chemistry.chemical_compound Rats Inbred BN Internal medicine medicine Animals Vitamin E Vitamin E Deficiency Arachidonic Acid Choroid business.industry Anti-Inflammatory Agents Non-Steroidal Retinal medicine.disease Crystallins Rats Ophthalmology Endocrinology chemistry Female Arachidonic acid business |
| Zdroj: | International Ophthalmology. 16:27-32 |
| ISSN: | 1573-2630 0165-5701 |
| DOI: | 10.1007/bf00917069 |
| Popis: | The anti-phlogistic effect of dietary vitamin E supplementation on the acute inflammation observed in experimental lens-induced uveitis in Brown Norway rats was studied. The effects of vitamin E were examined using histopathologic parameters as well as by measuring the levels of arachidonic acid metabolites. Histologic examination of the eyes revealed that the vitamin E-deficient animals had the most severe destruction of the retina, while those animals receiving the vitamin E-supplemented diet exhibited the best preservation of the retinal architecture. Levels of arachidonic acid metabolites, as determined by radioimmunoassay, were significantly higher in vitamin E deficient rats as compared with rats on a normal diet. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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