The impact of NOS3 gene polymorphism on papillary thyroid cancer susceptibility in patients undergoing radioiodine therapy
| Autor: | Izabel Cristina Rodrigues da Silva, Calliandra Maria de Souza Silva, Ligia Canongia de Abreu Cardoso Duarte, Caroline Ferreira Fratelli, Rafael Martins de Morais, Jamila Reis de Oliveira, Alaor Barra Sobrinho, Adara Rodrigues Damasceno Cerqueira, Alexandre Sampaio Rodrigues Pereira |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty endocrine system diseases Nitric Oxide Synthase Type III medicine.medical_treatment Clinical Biochemistry Polimorfismo genético Gastroenterology Pathology and Forensic Medicine Papillary thyroid cancer Iodine Radioisotopes Statistical significance Internal medicine Genotype medicine Humans Genetic Predisposition to Disease Thyroid Neoplasms Allele Thyroid cancer Polymorphism Genetic business.industry Thyroidectomy Odds ratio Middle Aged medicine.disease Confidence interval Tireóide - câncer Oncology Tireoidectomia Thyroid Cancer Papillary Case-Control Studies Female business Óxido nítrico |
| Zdroj: | Repositório Institucional da UnB Universidade de Brasília (UnB) instacron:UNB |
| ISSN: | 1724-6008 |
| Popis: | Thyroid cancer is the most common endocrine cancer in the world. Noting that the NOS3 gene polymorphism interferes with nitric oxide production, this study aims to identify and analyze the NOS3 gene polymorphism in the intron 4 region in patients with papillary thyroid cancer. A case-control study was conducted with 31 papillary thyroid cancer patients of both genders who underwent thyroidectomy and treatment with sodium iodide radiopharmaceutical (131I) compared with 81 control patients. Through papillary thyroid cancer, the results were observed, compiled, and analyzed using SPSS version 25.0. The significance level of 5% was adopted. Genotypic frequencies of healthy subjects were in the Hardy-Weinberg equilibrium ( P = 0.503). There was a significant genotypic difference between papillary thyroid cancer and healthy individuals ( P |
| Databáze: | OpenAIRE |
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