Differential Exercise Performance on Ventricular Assist Device Support
| Autor: | John Gorcsan, Robert L. Kormos, E. Stanford, Kaoru Dohi, S. Winowich, Srinivas Murali, Marc A. Simon, Lisa Carozza |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine medicine.medical_specialty Ventricular Dysfunction Right medicine.medical_treatment Hemodynamics Physical exercise law.invention Ventricular Dysfunction Left Oxygen Consumption law Internal medicine Artificial heart Exercise performance medicine Humans Exercise physiology Heart Failure Transplantation Exercise Tolerance business.industry Middle Aged equipment and supplies medicine.disease Surgery Ventricular assist device Heart failure Exercise Test Cardiology Female Heart-Assist Devices Cardiology and Cardiovascular Medicine business Destination therapy |
| Zdroj: | The Journal of Heart and Lung Transplantation. 24:1506-1512 |
| ISSN: | 1053-2498 |
| Popis: | Ventricular assist devices (VADs) are approved for destination therapy because they improve survival in end-stage heart failure (HF). VADs are powered pneumatically or electrically. Pneumatic and electric left ventricular assist devices (LVADs) and biventricular assist devices (BiVADs) provide excellent hemodynamic support at rest, but differences in their effects on exercise tolerance are unclear. We sought to evaluate the effect of devices with varying operating parameters on exercise capacity.Exercise physiology data obtained during maximal exercise with on-line gas-exchange analysis were collected for 38 consecutive VAD-implanted HF patients referred for exercise testing.Electric LVADs were implanted in 18 patients, and pneumatic LVADs in 10 patients. Percent of predicted peak exercise oxygen consumption (VO2%) was significantly greater in pneumatic LVAD patients (52.1 +/- 11.1% vs 38.2 +/- 11.3%, p0.05). The 10 patients implanted with a pneumatically powered LVAD were compared to 10 patients implanted with a pneumatically powered BiVAD. LVAD-supported patients had a higher VO2% (52.1 +/- 11.1% vs 36.5 +/- 17.7%, p0.05).HF patients supported with a pneumatic LVAD appear to have better exercise tolerance than those receiving an electric LVAD. Patients on LVAD support have better exercise tolerance than BiVAD-supported patients. This highlights the importance of right ventricular function to exercise tolerance in HF patients, and may have implications for future VAD design. |
| Databáze: | OpenAIRE |
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