Impaired insulin response after oral but not intravenous glucose in heart- and liver-transplant recipients
| Autor: | Michel Gillet, David A. D'Alessio, Oscar Matzinger, Luc Tappy, Halkic N, René Chioléro, Henchoz E, P. Schneiter, Goy Jj |
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| Jazyk: | angličtina |
| Rok vydání: | 2003 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty medicine.medical_treatment Glucose uptake Administration Oral Incretin Liver transplantation Body Mass Index Gastric inhibitory polypeptide Reference Values Internal medicine Diabetes mellitus Insulin Secretion medicine Humans Insulin Glucose homeostasis Infusions Intravenous Transplantation business.industry Blood Glucose/metabolism Female Glucose/administration & dosage Glucose Clamp Technique/methods Heart Transplantation/physiology Insulin/blood Insulin/secretion Liver Transplantation/physiology medicine.disease Liver Transplantation Glucose Endocrinology Glucose Clamp Technique Heart Transplantation business |
| Zdroj: | Transplantation, vol. 76, no. 6, pp. 923-929 |
| Popis: | BACKGROUND: The prevalence of diabetes is high after transplantation. We hypothesized that liver transplantation induces additional alterations of glucose homeostasis because of liver denervation. METHODS: Nondiabetic patients with a heart (n=9) or liver (n=9) transplant and healthy subjects (n=8) were assessed using a two-step hyperglycemic clamp (7.5 and 10 mmol/L). Thereafter, an oral glucose load (0.65 g/kg fat free mass) was administered while glucose was clamped at 10 mmol/L. Glucose appearance from the gut was calculated as the difference between glucose appearance (6,6 2H2 glucose) and exogenous glucose infusion. Plasma insulin, glucagon-like peptide (GLP)-1 and gastric inhibitory polypeptide(GIP) concentrations were compared after intravenous and oral glucose. RESULTS: After oral glucose, the glucose appearance from the gut was increased 52% and 81% in liver- and heart-transplant recipients (P |
| Databáze: | OpenAIRE |
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