Synthesis, biological evaluation and docking studies of methylene bearing cyanopyrimidine derivatives possessing a hydrazone moiety as potent Lysine specific demethylase-1 (LSD1) inhibitors: A promising anticancer agents

Autor:	Sharba Tasneem, Khursheed A. Sheikh, Md Naematullah, M. Mumtaz Alam, Farah Khan, Manika Garg, Mohd. Amir, Mymoona Akhter, Shaista Amin, Anzarul Haque, Mohammad Shaquiquzzaman
Rok vydání:	2022
Předmět:	Histone Demethylases Molecular Structure Lysine Organic Chemistry Hydrazones Antineoplastic Agents Biochemistry Molecular Docking Simulation Structure-Activity Relationship Cell Line Tumor Drug Design Drug Discovery Humans Drug Screening Assays Antitumor Molecular Biology Cell Proliferation
Zdroj:	Bioorganic chemistry. 126
ISSN:	1090-2120
Popis:	A series of novel cyanopyrimidine-hydrazone hybrids were synthesized and characterized with various spectroscopic techniques. The synthesized compounds were tested at NCI, USA, on a 60-cell line panel and most of the compounds showed remarkable cytotoxic activity against different cancer cell lines. Compound 5a was found to be the most potent compound of the series and it was further selected for five dose assays wherein it exhibited GI
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::594c021c1d6573d4b620a322de7ec113 https://pubmed.ncbi.nlm.nih.gov/35636128 Zobrazit plný text záznamu Full Text from ScienceDirect