5-Hydroxytryptophan (5-HTP) uptake and decarboxylation in the kitten brain
| Autor: | Ryohachi Arai, Kunio Kitahama, Ikuko Nagatsu, Mineko Fujimiya, Anne Jouvet |
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| Rok vydání: | 2002 |
| Předmět: |
Male
Aging Serotonin medicine.medical_specialty Monoamine Oxidase Inhibitors medicine.drug_class Central nervous system Sodium Chloride Decarboxylation Kitten 5-Hydroxytryptophan chemistry.chemical_compound biology.animal Internal medicine medicine Animals Tissue Distribution Biological Psychiatry Monoamine oxidase inhibitor biology Dopaminergic Tryptophan Brain Pons Drug Combinations Psychiatry and Mental health medicine.anatomical_structure Endocrinology Animals Newborn Pargyline Neurology chemistry Cats Medulla oblongata Female Neurology (clinical) |
| Zdroj: | Journal of Neural Transmission. 109:683-689 |
| ISSN: | 1435-1463 0300-9564 |
| Popis: | This study reports the presence of noradrenergic (NA) neurons which are capable to take up 5-hydroxytryptophan (5-HTP) and decarboxylate it to 5-hydroxytryptamine (5-HT serotonin) in the kitten brain. After loading of 5-HTP and monoamine oxidase inhibitor (MAOI), we could demonstrate 5-HT-immunoreactivity (IR) not only in hypothalamic and midbrain dopaminergic (DA) cell bodies, but also in NA ones located in the pons and medulla oblongata of the new born kitten aged from 1 to 7 days. NA cell bodies could no longer show 5-HT-IR after this treatment in the kitten older than 1 month. On the other hand, 5-HT-IR in the ventrolateral posterior hypothalamic (VLPH) cells was very weak at birth and became more and more intense after 15 days of age. Finally, after loading of tryptophan (TP) and MAOI, 5-HTP uptake cells mentioned above did not express 5-HT-IR in the kitten brain. |
| Databáze: | OpenAIRE |
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