Evaluation of Prognostic Factors for Survival in Transverse Colon Cancer

Autor: Francesca Lo Bianco, Alessandro Parisi, Federica Mazzuca, Ludovica Gariazzo, Giulia Arrivi, Claudia Angela Maria Fulgenzi, Fabio Gelsomino, Corrado Ficorella, Emanuela Dell'Aquila, Michele Ghidini, Andrea Montori, Federica Urbano, Stefano Cascinu, Maria Letizia Calandrella, Michela Roberto, Krisida Cerma, Alessio Cortellini, Marco Di Girolamo, Paolo Marchetti, Margherita Ratti, Alessandro Minelli, Emanuela Pilozzi, Francesco Caputo, Claudio Pizzo
Přispěvatelé: Roberto, M., Arrivi, G., Bianco, F. L., Cascinu, S., Gelsomino, F., Caputo, F., Cerma, K., Ghidini, M., Ratti, M., Pizzo, C., Ficorella, C., Parisi, A., Cortellini, A., Urbano, F., Calandrella, M. L., Dell'Aquila, E., Minelli, A., Fulgenzi, C. A. M., Gariazzo, L., Montori, A., Pilozzi, E., Di Girolamo, M., Marchetti, P., Mazzuca, F.
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Cancers
Volume 12
Issue 9
Cancers, Vol 12, Iss 2457, p 2457 (2020)
ISSN: 2072-6694
Popis: Background: Although most of the analyses included transverse colon cancers (TCC) among right colon cancer (RCC), it is not completely clear if they present total similarities with RCC or if they have their specific features. Therefore, we present an observational study to evaluate clinicopathological characteristics and survival data of patients with TCC. Methods: We retrospectively reviewed 450 RCC, of whom 97 stages I&ndash
IV TCC were included in this multicenter study
clinicopathological and molecular parameters were analyzed to identify prognostic factors for disease-free survival (DFS) and overall survival (OS). Results: Most of TCC cases were male (61%), with &le
70 years old (62%), and good performance status (ECOG PS 0, 68%). According to WHO classification, 41 (49%) and 40 (48%) tumors were classified as well to moderate and poorly/undifferentiated respectively, regardless of mucinous component (30%). About molecular data, 8 (26%), 45 (63%), and 14 (24%) were MSI-H, KRAS wild-type, and BRAF V600E mutant, respectively. With a median follow-up of 34 months, there were 29 and 50 disease recurrences and deaths respectively. Charlson comorbidity index &ge
5 was a significant prognostic factor for DFS (HR = 7.67, 95% CI 2.27&ndash
25.92). Colon obstruction/perforation (HR = 2.65, 95% CI 1.01&ndash
7.01), and BRAF mutant (HR = 3.03, 95% CI 0.97&ndash
9.50) cases showed a worst, despite not statistically significant, DFS. Whereas for OS, at the multivariate model, only tumor grade differentiation (HR = 5.26, 95% CI 1.98&ndash
14.01) and BRAF mutation status (3.71, 95% CI 1.07&ndash
12.89) were independent prognostic factors. Conclusions: Poorly/undifferentiated tumor grade and BRAF V600E mutation are independent prognostic factors for OS in TCC. Further prospective clinical trials are needed to better define TCC treatment in order to improve patient outcome.
Databáze: OpenAIRE
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