Using in situ Raman monitoring as a tool for rapid optimisation and scale-up of microwave-promoted organic synthesis: esterification as an example

Autor:	Rebecca J. Smith, T. Michael Barnard, Nicholas E. Leadbeater
Rok vydání:	2007
Předmět:	In situ Chemistry Organic Chemistry Analytical chemistry Chemical reactor Biochemistry symbols.namesake chemistry.chemical_compound Chemical engineering In situ raman spectroscopy SCALE-UP symbols Organic synthesis Physical and Theoretical Chemistry Raman spectroscopy Microwave
Zdroj:	Organicbiomolecular chemistry. 5(5)
ISSN:	1477-0520
Popis:	Microwave-promoted esterification reactions have been monitored using in situ Raman spectroscopy. Having optimised a reaction on a 23 mmol scale, it was transferred to a larger reaction vessel and scaled up to 0.26 mol, again with Raman monitoring. With conditions in hand, an automated stop-flow apparatus was used to prepare 5.7 moles of product.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5946711865171c49d8a19735d2bc042c https://pubmed.ncbi.nlm.nih.gov/17315069 Zobrazit plný text záznamu