18F-FDG PET/CT–Positive Internal Mammary Lymph Nodes: Pathologic Correlation by Ultrasound-Guided Fine-Needle Aspiration and Assessment of Associated Risk Factors
| Autor: | Carolyn L. Wang, J. David Beatty, James Rogers, Aleksandr Y. Aravkin, Marna Eissa, Bruce A. Porter |
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| Rok vydání: | 2013 |
| Předmět: |
Washington
medicine.medical_specialty Statistics as Topic Breast Neoplasms Multimodal Imaging Risk Assessment Sensitivity and Specificity Breast cancer Fluorodeoxyglucose F18 Prevalence Humans Medicine Radiology Nuclear Medicine and imaging Endoscopic Ultrasound-Guided Fine Needle Aspiration medicine.diagnostic_test business.industry Reproducibility of Results Retrospective cohort study General Medicine Middle Aged medicine.disease Metastatic breast cancer Fine-needle aspiration Positron emission tomography Lymphatic Metastasis Positron-Emission Tomography Female Fdg pet ct Radiology Lymph Tomography Radiopharmaceuticals Tomography X-Ray Computed business Nuclear medicine |
| Zdroj: | American Journal of Roentgenology. 200:1138-1144 |
| ISSN: | 1546-3141 0361-803X |
| DOI: | 10.2214/ajr.12.8754 |
| Popis: | Metastatic breast cancer in internal mammary (IM) lymph nodes is associated with a poor prognosis. This study correlates (18)F-FDG PET/CT-positive IM lymph nodes with ultrasound-guided fine-needle aspiration (FNA) cytopathologic results and determines risk factors for IM node positivity on PET/CT.For this retrospective study, a database search was performed to identify patients referred for whole-body (18)F-FDG PET/CT for initial staging or restaging of breast cancer from January 1, 2005, through December 31, 2010. The radiology reports and images were reviewed for patients with (18)F-FDG-avid IM lymph nodes on PET/ CT and correlated with the cytopathologic results from FNA of selected PET/CT-positive IM lymph nodes. The patients with positive IM nodes on PET/CT who underwent PET/CT for initial staging were compared against age-matched and tumor size-matched patients to identify risk factors for IM node positivity on PET/CT.One hundred ten of 1259 patients (9%) had an (18)F-FDG-avid IM lymph node on PET/CT. Twenty-five patients underwent ultrasound-guided FNA of a suspicious IM node, and 20 IM lymph nodes (80%) were cytologically proven metastases from the primary breast malignancy. High tumor grade, the presence of lymphovascular invasion (LVI), and triple receptor-negative hormonal receptor status were found to be significant risk factors for IM node positivity on PET/CT (p0.05).Although fewer than 10% of breast cancer patients have positive IM nodes on (18)F-FDG PET/CT performed for initial staging or restaging, a positive IM node indicates a very high likelihood of malignant involvement on ultrasound-guided FNA. The presences of high tumor grade, LVI, or triple receptor-negative status are risk factors for IM node positivity on (18)F-FDG PET/CT. |
| Databáze: | OpenAIRE |
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