The fate of the prion protein in the prion/plasminogen complex
| Autor: | Claude Balny, Michael C. Marden, Reinhard Lange, Stéphane Marchal, M. Judith Kornblatt, Jeanne Grosclaude, Marie-Pascale Debey, Gaston Hui Bon Hoa, Jack A. Kornblatt, Human Rezaei |
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| Přispěvatelé: | Concordia University (Concordia University), Institut National de la Santé et de la Recherche Médicale (INSERM), Unité de recherche Virologie et Immunologie Moléculaires (VIM (UR 0892)), Institut National de la Recherche Agronomique (INRA), Acides nucléiques : dynamique, ciblage, et fonctions biologiques - Régulation et dynamique des génomes (ANDCFB), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Muséum national d'Histoire naturelle (MNHN), Substitut du sang et pathologie moléculaire du globule rouge |
| Rok vydání: | 2003 |
| Předmět: |
Macromolecular Substances
Plasmin animal diseases Biophysics Cleavage (embryo) Biochemistry 03 medical and health sciences 0302 clinical medicine mental disorders medicine Animals Humans PrPC Proteins [SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular Biology Fibrinolysin Prion protein Molecular Biology 030304 developmental biology 0303 health sciences Sheep Chemistry Plasminogen Cell Biology Peptide Fragments nervous system diseases Tissue Plasminogen Activator Electrophoresis Polyacrylamide Gel 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Biochemical and Biophysical Research Communications Biochemical and Biophysical Research Communications, Elsevier, 2003, 305 (3), pp.518-522. ⟨10.1016/S0006-291X(03)00804-0⟩ |
| ISSN: | 0006-291X 1090-2104 |
| Popis: | International audience; The cellular prion protein (PrPc) forms complexes with plasminogen. Here, we show that the PrPc in this complex is cleaved to yield fragments of PrPc. The cleavage is accelerated by plasmin but does not appear to be dependent on it. |
| Databáze: | OpenAIRE |
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