Usefulness of neutrophil-to-lymphocyte ratio (NLR) as a prognostic predictor after treatment of hepatocellular carcinoma.' Review article
| Autor: | Shravani Reddy, Marrieth Rubio, Mohamad Mouchli, Miranda Gerrard, Lisa A. Boardman |
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| Rok vydání: | 2020 |
| Předmět: |
Oncology
medicine.medical_specialty Carcinoma Hepatocellular Neutrophils Specialties of internal medicine Cancer recurrence NLR 03 medical and health sciences 0302 clinical medicine LT Predictive Value of Tests Internal medicine Inflammatory marker Medicine Humans Lymphocyte Count Neutrophil to lymphocyte ratio Chemotherapy and other therapies Hepatology business.industry fungi Graft Survival Liver Neoplasms Patient survival General Medicine Resection medicine.disease Prognosis Review article Liver Transplantation Survival Rate RC581-951 030220 oncology & carcinogenesis Hepatocellular carcinoma Biomarker (medicine) 030211 gastroenterology & hepatology business HCC outcomes After treatment |
| Zdroj: | Annals of Hepatology, Vol 22, Iss, Pp 100249-(2021) |
| ISSN: | 1665-2681 |
| Popis: | The neutrophil-to-lymphocyte ratio (NLR) is an inflammatory marker which has been investigated as a prognostic indicator in post-therapeutic recurrence and survival of patients with HCC. Our aim was to review all studies that assessed the prognostic value of pre-treatment NLR in predicting patient survival, cancer recurrence, and graft survival in patients undergoing various therapies for HCC. We searched the database of PubMed and Google Scholar to review all studies that have the word “NLR” and the word “HCC.” We included all studies that assessed pre-treatment NLR as a prognostic factor in predicting outcomes in HCC patients. We excluded studies that assessed the correlation between post-treatment NLR or dynamic changes in NLR after treatment and HCC outcomes in an effort to minimize the confounding effect of each treatment on NLR. We reviewed 123 studies that studied the correlation between pre-treatment NLR and patient survival, 72 studies that evaluated the correlation between pre-treatment NLR and tumor recurrence, 21 studies that evaluated the correlation between NLR and tumor behavior, and 4 studies that assessed the correlation between NLR and graft survival. We found a remarkable heterogeneity between the methods of the studies, which is likely responsible for the differences in outcomes. The majority of the studies suggested a correlation between higher levels of pre-treatment NLR and poor outcomes. We concluded that NLR is a reliable and inexpensive biomarker and should be incorporated into other prognostic models to help determine outcomes following HCC treatment. |
| Databáze: | OpenAIRE |
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