The Gly482Ser polymorphism of the peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) is associated with type 2 diabetes in Tunisian population
| Autor: | Bochra Ftouhi, Imen Mahjoubi, Hedia Slimane, Riadh Jemaa, Amani Kallel, Chaker Sleimi, Naziha Kaabachi, Zeineb Jemaa, Moncef Feki |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Tunisia Genotype Endocrinology Diabetes and Metabolism Peroxisome proliferator-activated receptor Type 2 diabetes Polymerase Chain Reaction Polymorphism Single Nucleotide Polymorphism (computer science) Risk Factors Diabetes mellitus Internal medicine Internal Medicine medicine Humans Risk factor chemistry.chemical_classification business.industry Case-control study General Medicine Middle Aged medicine.disease Prognosis Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha Endocrinology chemistry Diabetes Mellitus Type 2 Case-Control Studies Female PPARGC1A business Biomarkers Polymorphism Restriction Fragment Length Follow-Up Studies Transcription Factors |
| Zdroj: | Diabetesmetabolic syndrome. 9(4) |
| ISSN: | 1878-0334 |
| Popis: | Background and aims Peroxisome proliferator-activated receptor-γ co-activator-1α (PGC-1α) is a transcriptional co-activator involved in adaptive thermogenesis, skeletal muscle metabolism, fatty acid oxidation, and gluconeogenesis. Several studies have suggested that the common PGC-1α polymorphism Gly482Ser (rs8192678) may be associated with risk of type 2 diabetes (T2D), with conflicting results. The aim of this study was to analyze whether the Gly482Ser variant is a risk factor for development of T2D in Tunisian population. Methods In a case–control study 487 unrelated patients with type 2 diabetes and 402 apparently healthy controls were recruited from January 2008 to August 2010. The Gly482Ser polymorphism was determined by PCR-RFLP analysis. Results A significant difference in genotypes distribution was observed between patients (Gly/Gly: 34.1%; Gly/Ser: 47.1%; Ser/Ser: 18.5%) and controls (Gly/Gly: 43.8%; Gly/Ser: 42.3%; Ser/Ser: 13.9%) ( χ 2 = 9.44, p = 0.009). The T2D patient group showed a significant higher frequency of the Ser allele compared to the controls (43% vs. 34%; OR: 1.35, 95% [CI]: 1.11–1.65, p = 0.002). The association between the Gly482Ser polymorphism and T2D remained significant after adjustment for other well-established cardiovascular risk factors. Conclusions In the current study, a significant and independent association between the Gly482Ser polymorphism (rs8192678) of the PGC-1α gene and T2D in the Tunisian population was found. |
| Databáze: | OpenAIRE |
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