Myocardial perfusion imaging using technetium-99m sestamibi in asymptomatic diabetic patients
| Autor: | Mohammadreza Pourbehi, A. Mohagheghie, D. K. Hedayat, M. N. Ahmadabadi, Majid Assadi |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Technetium Tc 99m Sestamibi medicine.medical_specialty Diabetic Cardiomyopathies Population Coronary Artery Disease Asymptomatic Sensitivity and Specificity Coronary artery disease Myocardial perfusion imaging Internal medicine medicine Humans Radiology Nuclear Medicine and imaging education education.field_of_study medicine.diagnostic_test business.industry Myocardial Perfusion Imaging Reproducibility of Results General Medicine Odds ratio Middle Aged medicine.disease Diabetes Mellitus Type 2 Angiography Cardiology Female Radiology medicine.symptom Radiopharmaceuticals business Perfusion Emission computed tomography |
| Zdroj: | Nuklearmedizin. Nuclear medicine. 50(1) |
| ISSN: | 0029-5566 |
| Popis: | SummaryMyocardial perfusion single-photon emission computed tomography (SPECT) has been extensively applied in the clinical assessment of patients with diabetes mellitus. The aim of the present study was to evaluate stress technetium- 99m sestamibi SPECT MPI perfusion in silent myocardial ischemia and its association with some clinical and laboratory parameters in an asymptomatic diabetic population. Patients, material, methods: 83 subjects (age: 57.1 ± 6.9 years) with at least five years history of type 2 diabetes, and no suspected or documented coronary artery disease (CAD) accomplished myocardial perfusion imaging; angiography was also performed in patients with abnormal MPI. Results: MPI results showed that 58 patients had normal myocardial perfusion, while 25 patients showed perfusion defects (23 reversible and 2 fixed) on MPI. 12 out of the 25 (48%) with abnormal MPI findings represented abnormal angiography. We observed that pretest likelihood of CAD (odds ratio 2.32; 95%-CI: 1.05–5.13; p = 0.038) and higher HbA1c level (odds ratio 1.70; 95%-CI, 1.07–2.71; p = 0.02) were independently associated with abnormal MPI. Conclusion: Occult CAD was present on MPI in 1/3 patients with DM without abnormal electro cardiographic findings or evidence of peripheral arterial disease. |
| Databáze: | OpenAIRE |
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