Activity of temafloxacin against respiratory pathogens
| Autor: | D. T. W. Chu, Nathan L. Shipkowitz, R N Swanson, J J Clement, Dwight J. Hardy |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
Ofloxacin medicine.drug_class Guinea Pigs Microbial Sensitivity Tests Quinolones Gram-Positive Bacteria medicine.disease_cause Haemophilus influenzae Microbiology Moraxella catarrhalis Mice Anti-Infective Agents Ciprofloxacin Streptococcus pneumoniae medicine Animals Pharmacology (medical) Respiratory Tract Infections Cells Cultured Antibacterial agent Pharmacology Dose-Response Relationship Drug biology Temafloxacin Bacterial Infections biochemical phenomena metabolism and nutrition bacterial infections and mycoses biology.organism_classification Quinolone respiratory tract diseases Infectious Diseases Female Gerbillinae Research Article Fluoroquinolones medicine.drug |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 35:423-429 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.35.3.423 |
| Popis: | The activity of the quinolone temafloxacin against respiratory pathogens was compared with those of ciprofloxacin and ofloxacin. MICs for 90% of strains tested indicated that temafloxacin was at least two- to fourfold more potent than the other two quinolones against Staphylococcus aureus, Streptococcus pneumoniae, and Legionella pneumophila. Temafloxacin had potency equal to that of ciprofloxacin and was twofold more active than ofloxacin against Streptococcus pyogenes. Moraxella catarrhalis, and Bordetella pertussis. Against Haemophilus influenzae and Klebsiella pneumoniae, temafloxacin was four- and twofold less potent than ciprofloxacin, respectively. When administered orally in mouse protection tests against S. aureus, S. pneumoniae, and S. pyogenes, temafloxacin was at least eight times more potent than ciprofloxacin and was two to four times more active than ofloxacin. Against H. influenzae, temafloxacin was as active as ofloxacin and was two times less active than ciprofloxacin following oral administration in mice. In treating L. pneumophila in guinea pigs and H. influenzae otitis media in gerbils, temafloxacin and ofloxacin were more effective than ciprofloxacin. Against S. pneumoniae otitis media in gerbils, temafloxacin and ciprofloxacin were more active than ofloxacin. Following subcutaneous administration in mice, temafloxacin achieved higher lung levels than ciprofloxacin or ofloxacin did. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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