| Autor: |
Miyo Ota, Kenneth B. Hoehn, Takayuki Ota, Carlos J. Aranda, Sara Friedman, Weslley F. Braga, Alefiyah Malbari, Steven H. Kleinstein, Scott H. Sicherer, Maria A. Curotto de Lafaille |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
bioRxiv |
| Popis: |
Food allergy is caused by allergen-specific IgE antibodies but little is known about the B cell memory of persistent IgE responses. Here we describe in human pediatric peanut allergy CD23+IgG1+memory B cells arising in type 2 responses that contain peanut specific clones and generate IgE cells on activation. These ‘type2-marked’ IgG1+memory B cells differentially express IL-4/IL-13 regulated genesFCER2/CD23, IL4R, and germlineIGHEand carry highly mutated B cell receptors (BCRs). Further, high affinity memory B cells specific for the main peanut allergen Ara h 2 mapped to the population of ‘type2-marked’ IgG1+memory B cells and included convergent BCRs across different individuals. Our findings indicate that CD23+IgG1+memory B cells transcribing germlineIGHEare a unique memory population containing precursors of pathogenic IgE.One-Sentence SummaryWe describe a unique population of IgG+memory B cells poised to switch to IgE that contains high affinity allergen-specific clones in peanut allergy. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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